Evidence map›Paper›PMID 34120891›Full record

ArticleAging2021

PirB functions as an intrinsic suppressor in hippocampal neural stem cells.

Baiyang Liu, Wenjing Cheng, Dating Cheng, Jun Pu, Zhi Nie, Cuifeng Xia, Yongbin Chen, Cuiping Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. LILRB4, an immune checkpoint on myeloid cells.Blood science (Baltimore, Md.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Baiyang LiuKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Wenjing ChengKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Dating ChengKunming Medical University, Kunming, Yunnan 650500, China.
Jun PuKunming Medical University, Kunming, Yunnan 650500, China.
Zhi NieKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Cuifeng XiaKunming Medical University, Kunming, Yunnan 650500, China.
Yongbin ChenKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Cuiping YangKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China.
Kunming Medical University · CNChinese Academy of Sciences · CNKunming Institute of Zoology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem cells play pivotal roles during prenatal development and throughout life. Here, we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during brain neurogenesis in the adult mouse. PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation and differentiation

Indexed as

AgingAnimalsCell DifferentiationCell Self RenewalHippocampusKruppel-Like Factor 4MiceMice, Inbred C57BLNeural Stem CellsPhosphorylationProto-Oncogene Proteins c-aktReceptors, ImmunologicSignal TransductionKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Pirb protein, mouseProto-Oncogene Proteins c-aktReceptors, ImmunologicAkt1neural stem cellsneurogenesisNSCspaired immunoglobulin-like receptor BPirB

Identifiers

PMID34120891
PMCPMC8266311
OpenAlexW3168739249

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.