Evidence map›Paper›PMID 34137371›Full record

ArticleeLife2021

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen.

Maria Danielle Sallee, Melissa A Pickett, Jessica L Feldman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Baicalein fromFrontiers in pharmacology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Apical PAR-3 caps orient the mitotic spindle inbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Epithelial morphogenesis, tubulogenesis and forces in organogenesis.Current topics in developmental biology · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria Danielle SalleeDepartment of Biology, Stanford University, Stanford, United States.ORCID 0000-0002-0144-2607
Melissa A PickettDepartment of Biology, Stanford University, Stanford, United States.
Jessica L FeldmanDepartment of Biology, Stanford University, Stanford, United States.ORCID 0000-0002-5210-5045
Stanford University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms controlling microtubule organization during cell differentiationDP2GM119136 · NIGMS · STANFORD UNIVERSITY · PI FELDMAN, JESSICA LYNN · 2015 to 2015
$2.4M
Investigating the establishment, structure, and function of microtubule organizing centers in differentiated cells in vivoR01GM133950 · NIGMS · STANFORD UNIVERSITY · PI FELDMAN, JESSICA LYNN · 2020 to 2023
$1.3M
In vivo polarity establishment and symmetry breaking in an epithelial tissueF32GM129900 · NIGMS · STANFORD UNIVERSITY · PI PICKETT, MELISSA ANNE · 2018 to 2020
$124k
Regulating the Coordination of Microtubule Organization and Cell Cycle StateF32GM120913 · NIGMS · STANFORD UNIVERSITY · PI SALLEE, MARIA DANIELLE · 2016 to 2018
$116k
NIGMS NIH HHS DP2 GM119136NIGMS NIH HHS F32 GM120913NIGMS NIH HHS F32 GM129900NIGMS NIH HHS R01 GM133950NIH HHS P40 OD010440
6 · The paper itself

Abstract

Sustained polarity and adhesion of epithelial cells is essential for the protection of our organs and bodies, and this epithelial integrity emerges during organ development amidst numerous programmed morphogenetic assaults. Using the developing

Indexed as

Epithelial CellsIntestinal MucosaAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsIntestinesLarvaMicrotubule-Organizing CenterProtein Kinase CCaenorhabditis elegans Proteinspar-6 protein, C elegansPKC-3 proteinProtein Kinase Capicobasal polarityCDC-42/Cdc42C. eleganscell biologycell-cell junctionsdevelopmental biologyepitheliaMTOCPAR-6/Par6, PKC-3/aPkc

Identifiers

PMID34137371
PMCPMC8245128
OpenAlexW3169565946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.