ArticleActa parasitologica2022
A 5-Year Prospective Study on Incidence and Clinico-pathological Changes Associated with Naturally Occurring Trypanosomosis in Dogs of Mizoram, India.
Article in Acta parasitologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- N-acetylcysteine as an adjunct therapy ameliorates oxidative stress and attenuates anaemia, acute phase response and hepatic injury in clinical Babesia gibsoni infection in dogs-a pilot study.Molecular biology reports · 2026Article
- Nephroprotective effects ofAnnals of medicine and surgery (2012) · 2025Article
- Alteration in oxidative/nitrosative disparity and nephroprotective effect of hydroethanolic extract ofAnnals of medicine and surgery (2012) · 2025Article
- Oxidative Stress in Canine Diseases: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2024Review
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10 authors at 3 institutions in 2 countries.
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Abstract
purposeThe present research was taken to study the hospital-based incidence and clinico-pathological changes associated with naturally occurring trypanosomosis in dogs of Mizoram.
methodsA 5-year prospective study on hospital-based incidence and clinico-pathological changes associated with naturally occurring trypanosomosis in dogs of Mizoram was carried out during the study period from April, 2015 to March, 2020. Trypanosoma evansi infection was confirmed by microscopic examination and polymerase chain reaction (PCR). Non-infected clinically healthy dogs (n = 6) served as control. Blood samples were collected to study the haemogram and serum samples were used for the evaluation of serum biochemical parameters and oxidant-antioxidant parameters.
resultsDuring the study period, an overall incidence of 0.25% was recorded for trypanosomosis in dogs. The most consistent clinical findings noticed were anorexia/inappetence, pyrexia, depression/lethargy, pale mucous membrane, dehydration and lymphadenomegaly. Anaemia, granulocytopenia, lymphocytosis and thrombocytopenia were the major findings noticed in trypanosomosis affected dogs. The profile of vital organ function revealed that the mean values of total protein, albumin and random blood glucose were significantly (P < 0.05) lower, whereas the mean values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin, blood urea nitrogen (BUN) and creatinine were significantly (P < 0.05) higher in dogs affected with trypanosomosis. The mean value of lipid hydroperoxide (LPO) was significantly (P < 0.05) higher, whereas the mean values of glutathione (GSH), superoxide dismutase (SOD) and total antioxidant activity (TAOA) were significantly (P < 0.05) lower in trypanosomosis affected dogs. When total erythrocyte count (TEC) was correlated with LPO (r = - 0.631, P < 0.05), a negative correlation was found, while in case of GSH (r = 0.757, P < 0.05), SOD (r = 0.767, P < 0.05) and TAOA (r = 0.713, P < 0.05), it was positively correlated.
conclusionA negative correlation of TEC count with LPO, while a positive correlation with GSH, SOD and TAOA signify the role of oxidative stress in the pathogenesis of anaemia induced by T. evansi infection in dogs. The present study findings might be helpful to clinicians when treating clinical cases of this kind. Incorporation of organ protective drugs and antioxidants in the treatment schedule may result in better prognosis.
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