ArticleNature communications2021
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Exosome biogenesis in arthropods: conserved mechanisms, experimental evidence, and emerging directions.Annals of the Entomological Society of America · 2026Review
- Contrasting epigenetics of Ixodes scapularis populations.Scientific reports · 2026Article
- Tick Extracellular Vesicles Alter Epidermal Keratinocyte Function.The Journal of investigative dermatology · 2026Article
- Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission.The EMBO journal · 2026Article
- Extracellular Vesicles in Arthropods: Biogenesis, Functions, Isolation Methods and Applications.Journal of extracellular vesicles · 2025Review
- Review
- Identification of PotentialVaccines · 2025Article
- Ticks' tricks: immunomodulatory effects of ixodid tick saliva at the cutaneous tick-host interface.Frontiers in immunology · 2025Review
- Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis.NPJ biofilms and microbiomes · 2024Article
- Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection.Nature microbiology · 2024Article
- Progress on the Regulation of the Host Immune Response by Parasite-Derived Exosomes.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Identification ofInfection and immunity · 2024Article
- Characterisation of extracellular vesicles in baculovirus infection ofJournal of extracellular biology · 2024Article
- Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness.Nature communications · 2024Article
- The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection.Parasites & vectors · 2024Article
- Overview of extracellular vesicles in pathogens with special focus on human extracellular protozoan parasites.Memorias do Instituto Oswaldo Cruz · 2024Review
- A glimpse into the world of microRNAs and their putative roles in hard ticks.Frontiers in cell and developmental biology · 2024Review
- Rab27 in tick extracellular vesicle biogenesis and infection.bioRxiv : the preprint server for biology · 2023Article
- Tick extracellular vesicles in host skin immunity and pathogen transmission.Trends in parasitology · 2023Review
Corrections and comments
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Authors and funding
33 authors at 11 institutions in 4 countries.
Adela S Oliva ChávezDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2397-0846
Xiaowei WangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Liron MarninDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8212-8985
Holly L HammondDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Erin E McClure CarrollDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Dana K ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5212-2494
Brenden G TullyDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Amanda D BuskirkCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Shelby L FordCenters for Disease Control and Prevention, Atlanta, GA, USA.
L Rainer ButlerDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Preeti ShahiDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Kateryna MorozovaDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Cristina C ClementDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Lauren LawresSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Anya J O' NealDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5188-1344
Choukri Ben MamounSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5028-1400
Kathleen L MasonUSDA, ARS, Animal Disease Research Unit, Washington State University, Pullman, WA, USA.
Brandi E HobbsDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9246-5486
Glen A ScolesUSDA, ARS, Animal Disease Research Unit, Washington State University, Pullman, WA, USA.
Eileen M BarryCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5326-0047
Daniel E SonenshineVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Jesus G ValenzuelaVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Marcela F PasettiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Michael L LevinCenters for Disease Control and Prevention, Atlanta, GA, USA.
Michail KotsyfakisInstitute of Parasitology, Biology Center of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.ORCID 0000-0002-7526-1876
Steven M JayFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.ORCID 0000-0002-3827-5988
Jason F HuntleyDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laura SantambrogioDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-4674-7041
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. jpedra@som.umaryland.edu.ORCID 0000-0001-8740-2667
University of Maryland, Baltimore · USAlbert Einstein College of Medicine · USCenters for Disease Control and Prevention · USJohns Hopkins University · USNational Institutes of Health · USUniversity of Maryland, College Park · USUniversity of Toledo · USYale University · USBiocon (Switzerland) · CHCzech Academy of Sciences · CZWashington State University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMolecular approaches to understand vector-host and vector-pathogen interactionsZIAAI000932 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI VALENZUELA, JESUS · 2009 to 2025
$23.1MTick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI UTPAL PAL · 2018 to 2026
$13.5MDevelopment of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9MUbiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2MTick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1MCorrelates of Vaccine-Induced, Tunable-Protection in an Outbred Tularemia ModelR01AI123129 · NIAID · ALBANY MEDICAL COLLEGE · PI BARRY, EILEEN M., HAZLETT, KARSTEN R.O. · 2016 to 2020
$3.7MControlling Exosome Noncoding RNA Cargo for Enhanced Wound HealingR01HL141611 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI JAY, STEVEN MICHAEL · 2018 to 2022
$1.9MBBA57-Mediated Borrelial Persistence, Genesis of Inflammation and ImmunityR01AI116620 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2015 to 2019
$1.9MIL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8MSTAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8MRegulation of Skin Immunity by a Tick BiteR21AI165520 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2022 to 2023
$425kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL141611NIAID NIH HHS F31 AI138440NIAID NIH HHS F31 AI152215NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI116620NIAID NIH HHS R01 AI123129NIAID NIH HHS R01 AI134696NIAID NIH HHS R21 AI165520NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665
Abstract
Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.
Indexed as
Anaplasma phagocytophilumAnimalsArthropodsBacterial InfectionsCell LineDermacentorExtracellular VesiclesFrancisella tularensisGene OntologyHumansInflammationIntravital MicroscopyIxodesMaleMiceMice, Inbred C57BLR-SNARE ProteinsVesicle-Associated Membrane Protein 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.