Evidence map›Paper›PMID 34143412›Full record

SynthesisSports medicine (Auckland, N.Z.)2021

Effects of Maternal Exercise During Pregnancy on Perinatal Growth and Childhood Obesity Outcomes: A Meta-analysis and Meta-regression.

Yanting Chen, Guiling Ma, Yun Hu, Qiyuan Yang, Jeanene M Deavila, Mei-Jun Zhu, Min Du

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  4. Can Group Exercise Programs Improve Health Outcomes in Pregnant Women? An Updated Systematic Review.International journal of environmental research and public health · 2022
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  8. Maternal exercise alters placental proteome in an exercise mode-specific manner.American journal of physiology. Endocrinology and metabolism · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yanting Chen *Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA.
Guiling Ma *College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Yun HuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, People's Republic of China.
Qiyuan YangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Jeanene M DeavilaCenter for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA.
Mei-Jun ZhuSchool of Food Science, Washington State University, Pullman, WA, 99164, USA.
Min DuCenter for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, 99164, USA. min.du@wsu.edu.ORCID http://orcid.org/0000-0002-7232-072X
Washington State University · USYangzhou University · CNUniversity of Massachusetts Chan Medical School · US

Funding

Maternal obesity, AMPK and fetal brown adipogenesisR01HD067449 · NICHD · WASHINGTON STATE UNIVERSITY · PI MIN DU · 2010 to 2026
$4.6M
NIH HHS R01-HD067449NIH HHS R21-AG049976
6 · The paper itself

Abstract

backgroundPerinatal growth abnormalities program susceptibility to childhood obesity, which is further exaggerated by maternal overweight and obesity (MO) during pregnancy. Exercise is highly accessible, but reports about the benefits of maternal exercise on fetal growth and childhood obesity outcomes are inconsistent, reducing the incentives for pregnant women to participate in exercise to improve children's perinatal growth.

objectiveThis systematic review and meta-analysis aims to establish evidence-based efficacy of exercise in mothers with normal weight (MNW) and MO during pregnancy in reducing the risks of perinatal growth abnormalities and childhood obesity. In addition, the impacts of exercise volume are also assessed.

methodsThe PubMed, ScienceDirect, Web of Science, and Cochrane Library databases were searched from inception to February 15, 2020. We included randomized controlled trials with exercise-only intervention or exercise with other confounders in pregnant MNW (body mass index, BMI 18.5-24.9 kg/m

results99 studies were included in the meta-analysis (n = 596,876), and individual study quality ranged from fair to good according to the Newcastle-Ottawa scale assessment. Exercise only interventions in MNW reduced preterm birth by 15% (26 studies, n = 76,132; odds ratio [OR] 0.85; 95% CI 0.72, 1.01; I

conclusionsThis systematic review and meta-analysis suggests that exercise during pregnancy in both MNW and MO safely and effectively reduce the risks of preterm birth, SGA, and LGA. Furthermore, MNW exercise also reduces the risk of childhood obesity. Overall, regardless of prepregnancy BMI, maternal exercise during pregnancy provides an excellent opportunity to mitigate the high prevalence of adverse birth outcomes and childhood obesity.

Indexed as

Pediatric ObesityPregnancy ComplicationsPremature BirthBirth WeightChildExerciseFemaleHumansInfantInfant, NewbornPregnancy

Identifiers

PMID34143412
OpenAlexW3170580486

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.