Evidence map›Paper›PMID 34145258›Full record

ArticleNature communications2021

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.

Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F Lacerda, António Campos, Sarah N Mapelli, Francesca Petroni and 12 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  8. Macrophage vacuolar ATPase (v-ATPase) function controlsbioRxiv : the preprint server for biology · 2025
    Article
  9. Observational
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Amyloid Fibrils Produced byInternational journal of molecular sciences · 2023
    Article
  17. Review
  18. The Impact of Acute Nutritional Interventions on the Plasma Proteome.The Journal of clinical endocrinology and metabolism · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 5 countries.

Andrea DoniIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Raffaella ParenteIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.ORCID 0000-0003-3607-1380
Ilaria LafaceIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Elena MagriniIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Cristina CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0002-6002-5782
Federico Simone ColomboIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.ORCID 0000-0003-4480-3481
João F LacerdaInstituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal.
António CamposServiço de Transplantação de Medula Óssea (STMO), Instituto Português de Oncologia do Porto, Porto, Portugal.
Sarah N MapelliIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Francesca PetroniIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Rémi PorteIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Tilo SchornIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.
Antonio InforzatoIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.ORCID 0000-0001-8110-0027
Toine MercierDepartment of Hematology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-1517-6426
Katrien LagrouDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8668-1350
Johan MaertensDepartment of Hematology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0003-4257-5980
John D LambrisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Barbara BottazziIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.ORCID 0000-0002-1930-9257
Cecilia GarlandaIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy.ORCID 0000-0002-1510-7703
Marina BottoDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID 0000-0002-1458-3791
Agostinho CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0001-8935-8030
Alberto MantovaniIRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy. alberto.mantovani@humanitasresearch.it.ORCID 0000-0001-5578-236X
IRCCS Humanitas Research Hospital · ITHumanitas University · ITKU Leuven · BEUniversity of Minho · PTHospital de Santa Maria · PTImperial College London · GBIPO Porto · PTUniversity of Ferrara · ITUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs

Indexed as

AnimalsAspergillus fumigatusCells, CulturedGenetic VariationHumansImmunity, InnateImmunocompromised HostInvasive Pulmonary AspergillosisLungMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPhagocytosisSerum Amyloid P-ComponentSerum Amyloid P-Component

Identifiers

PMID34145258
PMCPMC8213769
OpenAlexW3171181854

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.