Evidence map›Paper›PMID 34147126›Full record

ArticleVeterinary research2021

Lawsonia intracellularis infected enterocytes lack sucrase-isomaltase which contributes to reduced pig digestive capacity.

Emma T Helm, Eric R Burrough, Fernando L Leite, Nicholas K Gabler

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Efficiency of Commercial and Test Vaccines Against Lawsonia intracellularis on Clinical and Immunological Parameters in Swine: A Systematic Review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Pooled it
  2. Article
  3. Article
  4. Isolation, characterization, and pathogenic mechanisms of a novelFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Evaluation of F18 enterotoxigenicFrontiers in veterinary science · 2025
    Article
  7. Article
  8. Article
  9. Serological Assessment ofPathogens (Basel, Switzerland) · 2022
    Article
  10. Oral Vaccination Reduces the Effects ofFrontiers in veterinary science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emma T HelmDepartment of Animal Science, Iowa State University, Ames, IA, 50011, USA.
Eric R BurroughDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, 50011, USA.
Fernando L LeiteBoehringer Ingelheim Animal Health USA Inc, Duluth, GA, 30096, USA.
Nicholas K GablerDepartment of Animal Science, Iowa State University, Ames, IA, 50011, USA. ngabler@iastate.edu.ORCID http://orcid.org/0000-0001-7283-4782
Iowa State University · USBoehringer Ingelheim (United States) · US

Funding

National Institute of Food and Agriculture 2019-67015-29486
6 · The paper itself

Abstract

Lawsonia intracellularis is endemic to swine herds worldwide, however much is still unknown regarding its impact on intestinal function. Thus, this study aimed to characterize the impact of L. intracellularis on digestive function, and how vaccination mitigates these impacts. Thirty-six L. intracellularis negative barrows were assigned to treatment groups (n  =  12/trt): (1) nonvaccinated, L. intracellularis negative (NC); (2) nonvaccinated, L intracellularis challenged (PC); and (3) L. intracellularis challenged, vaccinated (Enterisol

Indexed as

AnimalsDesulfovibrionaceae InfectionsEnterocytesLawsonia BacteriaOligo-1,6-GlucosidaseSucraseSus scrofaSwineSwine DiseasesOligo-1,6-GlucosidaseSucraseCell proliferationDigestibilityIntestinal integrityLawsonia intracellularisNotch signalingVaccineWnt signaling

Identifiers

PMID34147126
PMCPMC8214296
OpenAlexW3175674532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.