Evidence map›Paper›PMID 34147662›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2021

Assessment of ultrasmall nanocluster for early and accurate detection of atherosclerosis using positron emission tomography/computed tomography.

Deborah Sultan, Wenjun Li, Lisa Detering, Gyu Seong Heo, Hannah P Luehmann, Daniel Kreisel, Yongjian Liu

Open access · greenAbstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Development of a CCR2 targetedNuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Deborah SultanMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
Wenjun LiDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Lisa DeteringMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
Hannah P LuehmannMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
Daniel KreiselDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. Electronic address: yongjianliu@wustl.edu.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA. Electronic address: yongjianliu@wustl.edu.
Mallinckrodt (United States) · USWashington University in St. Louis · US

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Wenjun Li · 2015 to 2026
$19.4M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
The Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6M
Leukocyte trafficking in thoracic graftsI01BX002730 · VA · ST. LOUIS VA MEDICAL CENTER · PI KREISEL, DANIEL · 2016 to 2025
–
BLRD VA I01 BX002730NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R35 HL145212NIAID NIH HHS P01 AI116501
6 · The paper itself

Abstract

The development of atherosclerosis therapy is hampered by the lack of molecular imaging tools to identify the relevant biomarkers and determine the dynamic variation in vivo. Here, we show that a chemokine receptor 2 (CCR2) targeted gold nanocluster conjugated with extracellular loop 1 inverso peptide (AuNC-ECL1i) determines the initiation, progression and regression of atherosclerosis in apolipoprotein E knock-out (ApoE

Indexed as

AtherosclerosisContrast MediaDrug Delivery SystemsGoldMetal NanoparticlesPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyAnimalsDisease Models, AnimalMiceMice, Knockout, ApoEContrast MediaGoldAtherosclerosisChemokine receptor 2NanoclusterPositron emission tomographyTargeting

Identifiers

PMID34147662
PMCPMC8684599
OpenAlexW3173607563

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.