Trial reportFrontiers in immunology2021
Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study.
Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Celiac Disease in Children with Idiopathic Nephrotic Syndrome-A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-mediated renal diseases.BMC gastroenterology · 2025Article
- Gut microbiota therapy for chronic kidney disease.Frontiers in immunology · 2025Review
- Celiac disease - a pluripathological model in pediatric practice.Frontiers in immunology · 2024Review
- Ketogenic metabolic therapy for chronic kidney disease - the pro part.Clinical kidney journal · 2024Review
- Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go.Vaccines · 2023Review
- Review
- Role of the Gut Microbiota in Children with Kidney Disease.Children (Basel, Switzerland) · 2023Article
- Review
- Gut Microbiota Alterations and Primary Glomerulonephritis in Children: A Review.International journal of molecular sciences · 2022Review
- Gluten-Free Diet in Childhood Difficult-to-Treat Nephrotic Syndrome: A Pilot Feasibility Study.Glomerular diseases · 2022Article
- Effect of gluten-free diet and antibiotics on murine gut microbiota and immune response to tetanus vaccination.PloS one · 2022Article
- Gluten-Free Diet Adherence and BMI z-Scores in Pediatric Celiac Disease: Distinguishing Recovery From Excess Weight Gain.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 9 institutions in 3 countries.
Funding
Abstract
Kidney disease affects 10% of the world population and is associated with increased mortality. Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage kidney disease in children, often failing standard immunosuppression. Here, we report the results of a prospective study to investigate the immunological impact and safety of a gluten-free and dairy-free (GF/DF) diet in children with SRNS. The study was organized as a four-week summer camp implementing a strict GF/DF diet with prospective collection of blood, urine and stool in addition to whole exome sequencing WES of DNA of participants. Using flow cytometry, proteomic assays and microbiome metagenomics, we show that GF/DF diet had a major anti-inflammatory effect in all participants both at the protein and cellular level with 4-fold increase in T regulatory/T helper 17 cells ratio and the promotion of a favorable regulatory gut microbiota. Overall, GF/DF can have a significant anti-inflammatory effect in children with SRNS and further trials are warranted to investigate this potential dietary intervention in children with SRNS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.