Trial reportJournal of Alzheimer's disease : JAD2021
Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk.
Trial report in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01041989 (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Trial
- Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- Genetic background and multidomain interventions in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial.Nature medicine · 2025Trial
- A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results.Alzheimer's research & therapy · 2024Trial
- Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- The Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) score as a predictor for cognitive decline and potential surrogate outcome in the FINGER lifestyle randomized controlled trial.European journal of neurology · 2024Trial
- Improving Adherence to a Mediterranean Ketogenic Nutrition Program for High-Risk Older Adults: A Pilot Randomized Trial.Nutrients · 2023Trial
- Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024).The Lancet regional health. Southeast Asia · 2026Article
- Screening for Alzheimer's disease in the community using an AI-driven screening platform: design of the PREDICTOM study.The journal of prevention of Alzheimer's disease · 2026Article
- Prevention of dementia using mobile phone applications (PRODEMOS) - a health-economic cost-utility analysis in people aged 55-75 years with low socio-economic status.The journal of prevention of Alzheimer's disease · 2026Article
- Concurrent detection of cognitive impairment and amyloid positivity with a multimodal machine learning-enabled digital cognitive assessment.Alzheimer's research & therapy · 2025Article
- Identifying the optimal combinations of modifiable dementia risk factors to target in multidomain intervention - Three-year longitudinal findings from the Canadian longitudinal study on aging.The journal of prevention of Alzheimer's disease · 2025Article
- Multidomain interventions for prevention of dementia: Achievements, challenges and future perspectives.Geriatrics & gerontology international · 2025Review
- Intrinsic factors associated with engagement in healthy lifestyle behaviors for dementia risk reduction in midlife.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Exploring Older Adults' Pre-Intervention Motivations, Attitudes, Expectations, and Barriers to Participation in the FINGER-NL Lifestyle Intervention to Maintain Optimal Cognitive Functioning: A Qualitative Interview Study.Ageing international · 2025Article
- Dual cognitive and mobility impairments and future dementia - Setting a research agenda.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Polygenic risk of type 2 diabetes is associated with incident vascular dementia: a prospective cohort study.Brain communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.