Evidence mapPaperPMID 34152000Full record

ReviewClinical and experimental immunology2021

Clinical and neuroimaging findings in MOGAD-MRI and OCT.

Frederik Bartels, Angelo Lu, Frederike Cosima Oertel, Carsten Finke, Friedemann Paul, Claudia Chien

Abstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. U-Fiber Enhancement in MOGAD: Extending the Meningo-Cortical Spectrum.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  18. Impact of autoantibodies against myelin oligodendrocyte glycoprotein in paediatric acquired demyelinating disease: Intellectual functioning and academic performance.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2024
    Article
  19. Article
  20. NMOSD and MOGAD: an evolving disease spectrum.Nature reviews. Neurology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frederik BartelsDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Angelo LuHumboldt-Universität zu Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Experimental and Clinical Research Center, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin, Germany.
Frederike Cosima OertelHumboldt-Universität zu Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Experimental and Clinical Research Center, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin, Germany.
Carsten FinkeDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Friedemann PaulDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Claudia ChienHumboldt-Universität zu Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Experimental and Clinical Research Center, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin, Germany.ORCID 0000-0001-8280-9513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies.

Indexed as

Aquaporin 4AutoantibodiesBrainEncephalomyelitis, Acute DisseminatedHumansImmunoglobulin GMagnetic Resonance ImagingMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinNeuroimagingNeuromyelitis OpticaOptic NerveRetinaSpinal CordTomography, Optical CoherenceAQP4 protein, humanAquaporin 4AutoantibodiesImmunoglobulin GMyelin-Oligodendrocyte Glycoproteinmagnetic resonance imagingmyelin oligodendrocyte glycoprotein associated disordersoptical coherence tomography

Identifiers

PMID34152000
PMCPMC8561692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.