Evidence map›Paper›PMID 34158498›Full record

ArticleNature communications2021

Artificially engineered antiferromagnetic nanoprobes for ultra-sensitive histopathological level magnetic resonance imaging.

Zeyu Liang, Qiyue Wang, Hongwei Liao, Meng Zhao, Jiyoung Lee, Chuang Yang, Fangyuan Li, Daishun Ling

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  5. Unveiling Dipolar Interaction-Driven Magnetic Field Inhomogeneities in TAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeyu Liang *Institute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Qiyue Wang *Institute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Hongwei Liao *Institute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Meng ZhaoInstitute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Jiyoung LeeInstitute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Chuang YangInstitute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Fangyuan LiInstitute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
Daishun LingInstitute of Pharmaceutics and College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. dsling@sjtu.edu.cn.ORCID 0000-0002-9977-0237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histopathological level imaging in a non-invasive manner is important for clinical diagnosis, which has been a tremendous challenge for current imaging modalities. Recent development of ultra-high-field (UHF) magnetic resonance imaging (MRI) represents a large step toward this goal. Nevertheless, there is a lack of proper contrast agents that can provide superior imaging sensitivity at UHF for disease detection, because conventional contrast agents generally induce T2 decaying effects that are too strong and thus limit the imaging performance. Herein, by rationally engineering the size, spin alignment, and magnetic moment of the nanoparticles, we develop an UHF MRI-tailored ultra-sensitive antiferromagnetic nanoparticle probe (AFNP), which possesses exceptionally small magnetisation to minimize T2 decaying effect. Under the applied magnetic field of 9 T with mice dedicated hardware, the nanoprobe exhibits the ultralow r

Indexed as

MagneticsAnimalsCell Line, TumorContrast MediaHumansMagnetic Resonance ImagingMaleMiceMice, Inbred BALB CMice, NudeMicroscopy, Electron, TransmissionNanoparticlesNeoplasmsRatsRats, WistarRAW 264.7 CellsContrast Media

Identifiers

PMID34158498
PMCPMC8219830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.