Evidence map›Paper›PMID 34160252›Full record

ArticleJournal of virology2021

A Novel Strain-Specific Neutralizing Epitope on Glycoprotein H of Human Cytomegalovirus.

Marco Thomas, Barbara Kropff, Andrea Schneider, Thomas H Winkler, Irene Görzer, Heinrich Sticht, William J Britt, Michael Mach, Nina Reuter

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Marco ThomasVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Barbara KropffVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Andrea SchneiderNikolaus-Fiebiger-Zentrum für Molekulare Medizin, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Thomas H WinklerNikolaus-Fiebiger-Zentrum für Molekulare Medizin, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Irene GörzerCenter for Virology, Medical University of Vienna, Vienna, Austria.
Heinrich StichtInstitut für Biochemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
William J BrittDepartments of Pediatrics, Microbiology and Neurobiology, Children's Hospital of Alabama, University of Alabama, School of Medicine, Birmingham, Alabama, USA.
Michael MachVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Nina ReuterVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEMedical University of Vienna · ATUniversity of Alabama · US

Funding

Congenital CMV and CNS Infection Mechanisms of Protective ImmunityR01AI089956 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI William Jarvis Britt · 2011 to 2026
$7.7M
Identification of pre-fusion conformers of HCMV gBR21AI126886 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MACH, MICHAEL · 2016 to 2017
$358k
Deutsche Forschungsgemeinschaft (DFG) 401821119/GRK2504HHS | NIH | OSC | Common Fund (NIH Common Fund) 1R21AI126886-01NIAID NIH HHS R01 AI089956NIAID NIH HHS R21 AI126886
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe clinical disease in immunosuppressed patients and congenitally infected newborn infants. Viral envelope glycoproteins represent attractive targets for vaccination or passive immunotherapy. To extend the knowledge of mechanisms of virus neutralization, monoclonal antibodies (MAbs) were generated following immunization of mice with HCMV virions. Hybridoma supernatants were screened for

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCytomegalovirusCytomegalovirus InfectionsEpitopesHEK293 CellsHumansMiceMice, Inbred BALB CViral Envelope ProteinsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesglycoprotein H, Human cytomegalovirusViral Envelope Proteinsglycoprotein Hherpesviruseshuman cytomegalovirusneutralizing antibodies

Identifiers

PMID34160252
PMCPMC8387041
OpenAlexW3176791018

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.