Evidence map›Paper›PMID 34160402›Full record

SynthesisMedicine2021

Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis.

Renjie Liu, Yongle Zhan, Jianmin Piao, Zhongxi Yang, Yun Wei, Pengcheng Liu, Xuan Chen, Yu Jiang

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Angiographic predictors of spontaneous obliteration of transarterial partially embolized brain arteriovenous malformations.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Renjie LiuDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Yongle ZhanDepartment of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Jianmin PiaoDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Zhongxi YangDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Yun WeiDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Pengcheng LiuDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Xuan ChenDepartment of Neurovascular Surgery, The First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province.
Yu JiangDepartment of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
First Bethune Hospital of Jilin University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe best therapeutic option for unruptured brain arteriovenous malformations (bAVMs) patients is disputed.

objectiveTo assess the occurrence of obliteration and complications of patients with unruptured bAVMs after various treatments.

methodsA systematic literature search was performed in PubMed, EMBASE, Web of Science, and so on to identify studies fulfilling predefined inclusion criteria. Baseline, treatment, and outcomes data were extracted for statistical analysis.

resultsWe identified 28 eligible studies totaling 5852 patients. The obliteration rates were 98% in microsurgery group (95% confidence interval (CI): 96%-99%, I2 = 74.5%), 97% in surgery group (95%CI: 95%-99%, I2 = 18.3%), 87% in endovascular treatment group (95%CI: 80%-93%, I2 = 0.0%), and 68% in radiosurgery group (95%CI: 66%-69%, I2 = 92.0%). The stroke or death rates were 1% in microsurgery group (95%CI: 0%-2%, I2 = 0.0%), 0% in surgery group (95%CI: 0%-1%, I2 = 0.0%), 4% in endovascular treatment group (95%CI: 0%-8%, I2 = 85.8%), and 3% in radiosurgery group (95%CI: 3%-4%, I2 = 82.9%). In addition, the proportions of hemorrhage were 2% in microsurgery group (95%CI: 1%-4%, I2 = 0.0%), 23% in endovascular treatment group (95%CI: 7%-39%), and 12% in radiosurgery group (95%CI: 12%-13%, I2 = 99.2%). As to neurological deficit, the occurrence was 9% in microsurgery group (95%CI: 6%-11%, I2 = 94.1%), 20% in surgery group (95%CI: 13%-27%, I2 = 0.0%), 14% in endovascular treatment group (95%CI: 10%-18%, I2 = 64.0%), and 8% in radiosurgery group (95%CI: 7%-9%, I2 = 66.6%).

conclusionsWe found that microsurgery might provide lasting clinical benefits in some unruptured bAVMs patients for its high obliteration rates and low hemorrhage. These findings are helpful to provide a reference basis for neurosurgeons to choose the treatment of patients with unruptured bAVMs.

Indexed as

Intracranial Arteriovenous MalformationsIntracranial HemorrhagesNeurosurgical ProceduresStrokeEndovascular ProceduresHumansMicrosurgeryRadiosurgeryTreatment Outcome

Identifiers

PMID34160402
PMCPMC8238300
OpenAlexW3173960003

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.