Evidence map›Paper›PMID 34168250›Full record

ArticleScientific reports2021

High prevalence of symptoms among Brazilian subjects with antibodies against SARS-CoV-2.

Ana M B Menezes, Cesar G Victora, Fernando P Hartwig, Mariângela F Silveira, Bernardo L Horta, Aluísio J D Barros, Marilia A Mesenburg, Fernando C Wehrmeister, Lúcia C Pellanda, Odir A Dellagostin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Prevalence and Factors Associated with Olfactory Dysfunction in Individuals with COVID-19 in Brazil: A Study of 20,669 Cases from 2020 to 2021.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Article
  3. Seroprevalence of SARS-CoV-2 in hospital workers in the southern region of Minas Gerais state in Brazil: An analysis of the pre-vaccine period.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ana M B MenezesUniversidade Federal de Pelotas, Pelotas, Brazil. anamene.epi@gmail.com.ORCID 0000-0002-2996-9427
Cesar G VictoraUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0002-2465-2180
Fernando P HartwigUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0003-3729-0710
Mariângela F SilveiraUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0002-2861-7139
Bernardo L HortaUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0001-9843-412X
Aluísio J D BarrosUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0002-2022-8729
Marilia A MesenburgUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0001-9598-4193
Fernando C WehrmeisterUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0001-7137-1747
Lúcia C PellandaFundação Universidade Federal de Ciências de Saúde de Porto Alegre, Porto Alegre, Brazil.ORCID 0000-0002-4593-3416
Odir A DellagostinUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0003-2803-4088
Cláudio J StruchinerFundação Getúlio Vargas, Rio de Janeiro, Brazil.ORCID 0000-0003-2114-847X
Marcelo N BurattiniUniversidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-5407-6890
Fernando C BarrosUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0001-5973-1746
Pedro C HallalUniversidade Federal de Pelotas, Pelotas, Brazil.ORCID 0000-0003-1470-6461
Universidade Federal de Pelotas · BRFundação Getulio Vargas · BRUniversidade de São Paulo · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the beginning of the pandemic of COVID-19, there has been a widespread assumption that most infected persons are asymptomatic. Using data from the recent wave of the EPICOVID19 study, a nationwide household-based survey including 133 cities from all states of Brazil, we estimated the proportion of people with and without antibodies for SARS-CoV-2 who were asymptomatic, which symptoms were most frequently reported, number of symptoms and the association with socio-demographic characteristics. We tested 33,205 subjects using a rapid antibody test previously validated. Information was collected before participants received the test result. Out of 849 (2.7%) participants positive for SARS-CoV-2 antibodies, only 12.1% (95% CI 10.1-14.5) reported no symptoms, compared to 42.2% (95% CI 41.7-42.8) among those negative. The largest difference between the two groups was observed for changes in smell/taste (56.5% versus 9.1%, a 6.2-fold difference). Changes in smell/taste, fever and body aches were most likely to predict positive tests as suggested by recursive partitioning tree analysis. Among individuals without any of these three symptoms, only 0.8% tested positive, compared to 18.3% of those with both fever and changes in smell or taste. Most subjects with antibodies against SARS-CoV-2 are symptomatic, even though most present only mild symptoms.

Indexed as

COVID-19AdolescentAdultAgedAntibodies, ViralBrazilCarrier StateChildChild, PreschoolFemaleHumansImmunoglobulin GImmunoglobulin MInfantInfant, NewbornMaleAntibodies, ViralImmunoglobulin GImmunoglobulin M

Identifiers

PMID34168250
PMCPMC8225900
OpenAlexW3173908044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.