ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021
Associations Between Serum Free Fatty Acid Levels and Incident Diabetes in a 3-Year Cohort Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Association between free fatty acids and adverse outcomes in patients with and without diabetes undergoing percutaneous coronary intervention.Journal of translational internal medicine · 2026Article
- The association between TyG index and hypertension in middle-aged and elderly Chinese patients: Data from CHALRS.PloS one · 2025Article
- Article
- Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control.Biomedicines · 2023Review
- Article
- Effects of Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh circulating free fatty acid (FFA) is associated with the development of diabetes. This study was designed to evaluate longitudinal associations between FFA levels, changes in FFA levels, and mean FFA levels and incident diabetes. PARTICIPANTS AND
methodsThis 3-year cohort study was conducted in Ningyang between 2011 and 2014. Serum FFA, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) levels were measured at baseline and at the end of follow-up. A multivariate stepwise logistic regression model was used to evaluate associations between serum FFA levels in various groups and the risk of incident diabetes.
resultsOf the 2905 individuals without baseline diabetes, 290 developed diabetes by the 3-year follow-up. With increasing baseline FFA levels, the mean FPG, 2hPG, and HbA1c levels, and the prevalence of diabetes at the end of follow-up increased. The trend of FPG and HbA1c increase was not statistically significant. Higher baseline FFA levels were not significantly associated with greater risk of incident diabetes. However, longitudinal changes in serum FFA levels showed that individuals with serum FFA levels from normal to high (OR = 2.956, 95% CI: 2.089-4.184) or from high to high (OR = 3.343, 95% CI: 2.300-4.857) had greater risk of incident diabetes compared with those with normal to normal FFA levels. Similarly, individuals with ΔFFA ≥ 0 mmol/L (OR = 1.762, 95% CI: 1.373-2.262) or high mean serum FFA levels (OR = 2.120, 95% CI: 1.620-2.775) were at higher risk of incident diabetes than those with ΔFFA < 0 mmol/L or normal mean serum FFA levels.
conclusionThe longitudinal status of serum FFA levels, including chronic increases and sustained high levels, was more closely associated with high risk of incident diabetes than was high baseline FFA levels.
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