Evidence map›Paper›PMID 34170489›Full record

SynthesisEating and weight disorders : EWD2022

Gender-based clinical differences in evidence-based treatment for adolescent anorexia nervosa: analysis of aggregated randomized controlled trials.

Sasha Gorrell, Elizabeth K Hughes, Susan M Sawyer, Savannah R Roberts, Jason M Nagata, Michele Yeo, James Lock, Daniel Le Grange

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sasha GorrellDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, 401 Parnassus Avenue, San Francisco, CA, 94143, USA. Sasha.Gorrell@ucsf.edu.ORCID http://orcid.org/0000-0002-8861-8547
Elizabeth K HughesDepartment of Paediatrics, The University of Melbourne, Melbourne, Australia.
Susan M SawyerDepartment of Paediatrics, The University of Melbourne, Melbourne, Australia.
Savannah R RobertsDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA.
Jason M NagataDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Michele YeoDepartment of Paediatrics, The University of Melbourne, Melbourne, Australia.
James LockDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Daniel Le GrangeDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, 401 Parnassus Avenue, San Francisco, CA, 94143, USA.

Funding

Treatment of Adolescents with Anorexia NervosaR01MH070621 · STANFORD UNIVERSITY · 2004 to 2005
$867k
Neural Correlates of Reinforcement Learning Specific to Hyperactivityin Adolescent Anorexia NervosaK23MH126201 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$170k
Foundation for the National Institutes of Health K23MH126201Foundation for the National Institutes of Health R01-MH-070621NIMH NIH HHS K23 MH126201NIMH NIH HHS R01 MH070621NINDS NIH HHS R25 NS117367
6 · The paper itself

Abstract

purposeBoys represent a small proportion of samples in randomized clinical trials (RCT) investigating evidence-based treatment for adolescents with anorexia nervosa (AN). Consequently, knowledge of potential gender differences in clinical characteristics and treatment response in adolescents is considerably limited.

methodsSecondary analyses of aggregated data from two RCTs were used to characterize baseline and end-of-treatment clinical features in male and female adolescents with AN (n = 228, 10.53% male). Mixed analyses of variance were used to investigate potential gender differences in treatment response relative to weight outcomes (% median BMI) and eating disorder cognitions (Eating Disorder Examination Global scores; EDE).

resultsThere were no significant gender differences in prior inpatient care, illness duration, psychiatric comorbidity, or psychotropic medication use at baseline. Nor were there significant gender differences in binge eating, purging, or driven exercise at baseline or end-of-treatment. Girls reported elevated weight and shape concern compared to boys at baseline but overall reduction in EDE Global scores over the course of treatment did not differ according to gender. Boys gained more relative weight during treatment than girls, but this difference was statistically non-significant.

conclusionOverall findings do not suggest significant differences in treatment outcome relative to weight or ED cognitions, by gender. Current evidence suggests that, with the exception of shape and weight concerns, boys present with cognitive and behavioral symptoms as severe as their female counterparts which underscores the need for increased accuracy in assessment of these disorders in boys and young men. LEVEL OF EVIDENCE: Level 1, secondary data analysis of randomized controlled trials.

Indexed as

Anorexia NervosaBinge-Eating DisorderFeeding and Eating DisordersAdolescentFemaleHumansMaleRandomized Controlled Trials as TopicSex FactorsAdolescentsAnorexia nervosaBoysEating disorder treatmentGender

Identifiers

PMID34170489
PMCPMC8796313

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.