Evidence map›Paper›PMID 34175303›Full record

ArticleJournal of molecular and cellular cardiology2021

Triiodothyronine maintains cardiac transverse-tubule structure and function.

Nimra Gilani, Kaihao Wang, Adam Muncan, Jerrin Peter, Shimin An, Simran Bhatti, Khushbu Pandya, Youhua Zhang, Yi-Da Tang, A Martin Gerdes and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nimra GilaniDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: ngilani@nyit.edu.
Kaihao WangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Adam MuncanDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: amuncan@nyit.edu.
Jerrin PeterDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: jpeter@nyit.edu.
Shimin AnDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Simran BhattiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: sbhatt12@nyit.edu.
Khushbu PandyaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: kpandy04@nyit.edu.
Youhua ZhangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: yzhang49@nyit.edu.
Yi-Da TangDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
A Martin GerdesDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: martin.gerdes@nyit.edu.
Randy F StoutDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA; NYIT Imaging Center, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: rstout@nyit.edu.
Kaie OjamaaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Northern Blvd., Old Westbury, New York 11568, USA. Electronic address: kojamaa@nyit.edu.
New York Institute of Technology · USChinese Academy of Medical Sciences & Peking Union Medical College · CNImaging Center · US

Funding

Thyroid hormone regulation of cardiomyocyte T-tubule structureand functionR15HL154068 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI OJAMAA, KAIE MARGAREETA · 2020 to 2020
$428k
NHLBI NIH HHS R15 HL154068
6 · The paper itself

Abstract

Subclinical hypothyroidism and low T3 syndrome are commonly associated with an increased risk of cardiovascular disease (CVD) and mortality. We examined effects of T3 on T-tubule (TT) structures, Ca

Indexed as

AnimalsCalciumCalcium Channels, L-TypeCalcium SignalingCells, CulturedDisease Models, AnimalFemaleGene ExpressionHeart VentriclesHypothyroidismMembrane ProteinsMyocytes, CardiacRatsRyanodine Receptor Calcium Release ChannelSarcolemmaSarcomeresCalciumCalcium Channels, L-TypejunctophilinMembrane ProteinsRyanodine Receptor Calcium Release ChannelRyR2 protein, ratTriiodothyronineCa(2+)Junctophilin-2Ryanodine receptorsSTORMThyroid hormoneTransverse-tubules

Identifiers

PMID34175303
PMCPMC8570994
OpenAlexW3173198494

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.