Evidence map›Paper›PMID 34178669›Full record

ArticleFrontiers in oncology2021

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value.

Yukun Li, Juan Zou, Qunfeng Zhang, Feifei Quan, Lu Cao, Xiaodi Zhang, Jue Liu, Daichao Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yukun LiDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Juan ZouDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Qunfeng ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Feifei QuanDepartment of Obstetrics and Gynecology, Foshan First People's Hospital, Foshan, China.
Lu CaoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Xiaodi ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Jue LiuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Daichao WuClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, China.
University of South China · CNFirst People's Hospital of Foshan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microliposome maintenance (MCM) 2, MCM3, MCM4, MCM5, MCM6, and MCM7 are DNA replication regulators and are involved in the progression of multiple cancer types, but their role in ovarian cancer is still unclear. The purpose of this study is to clarify the biological function and prognostic value of the MCM complex in ovarian cancer (OS) progression. We analyzed DNA alterations, mRNA and protein levels, protein structure, PPI network, functional enrichment, and prognostic value in OC based on the Oncomine, cBioPortal, TCGA, CPTAC, PDB, GeneMANIA, DAVID, KEGG, and GSCALite databases. The results indicated that the protein levels of these DNA replication regulators were increased significantly. Moreover, survival analysis showed a prognostic signature based on the MCM complex, which performed moderately well in terms of OS prognostic prediction. Additionally, protein structure, functional enrichment, and PPI network analyses indicated that the MCM complex synergistically promoted OC progression by accelerating DNA replication and the cell cycle. In conclusion, our study suggested that the MCM complex might be a potential target and prognostic marker for OC patients.

Indexed as

comprehensive bioinformaticsovarian cancerprognostic valuepublic databasesThe minichromosome maintenance (MCM) complex

Identifiers

PMID34178669
PMCPMC8220296
OpenAlexW3168034064

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.