Evidence map›Paper›PMID 34180835›Full record

ArticleeLife2021

High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective

Rachel C Findlay, Mohamed Osman, Kirstin A Spence, Paul M Kaye, Pegine B Walrad, Laurence G Wilson

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Virulence · 2025
    Article
  3. Species-specific surface dwell times and accumulation of microbes investigated by holographic microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  4. Chemotactic behaviour ofParasitology · 2025
    Article
  5. Role of a single MCP in evolutionary adaptation ofApplied and environmental microbiology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. New Vistas in the Biology of the Flagellum-Pathogens (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rachel C FindlayYork Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom.ORCID 0000-0003-3235-130X
Mohamed OsmanYork Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom.
Kirstin A SpenceYork Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom.ORCID 0000-0002-1220-4698
Paul M KayeYork Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom.ORCID 0000-0002-8796-4755
Pegine B WalradYork Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom.ORCID 0000-0002-2302-0720
Laurence G WilsonDepartment of Physics, University of York, York, United Kingdom.ORCID 0000-0001-6659-6001
University of York · GB

Funding

BBSRC BB/M011151/1Engineering and Physical Sciences Research Council EP/N014731/1Medical Research Council MR/L00092X/1Wellcome TrustWellcome Trust WT104726Wellcome Trust WT105502MA
6 · The paper itself

Abstract

Cellular motility is an ancient eukaryotic trait, ubiquitous across phyla with roles in predator avoidance, resource access, and competition. Flagellar motility is seen in various parasitic protozoans, and morphological changes in flagella during the parasite life cycle have been observed. We studied the impact of these changes on motility across life cycle stages, and how such changes might serve to facilitate human infection. We used holographic microscopy to image swimming cells of different

Indexed as

ChemotaxisHost-Parasite InteractionsImaging, Three-DimensionalHumansLeishmania mexicanaSpecies Specificitychemotaxisimage analysisinfectious diseaseLeishmania mexicanamicrobiologyoptical microscopyphysics of living systems

Identifiers

PMID34180835
PMCPMC8238501
OpenAlexW3177211382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.