ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2021
Evaluation of Nonlinear Contrast Pulse Sequencing for Use in Super-Resolution Ultrasound Imaging.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Super-resolution contrast-enhanced ultrasound: recent advances.Ultrasonography (Seoul, Korea) · 2026Article
- Imaging of macrophage accumulation in solid tumors with ultrasound.Nature communications · 2025Article
- Modulating Nonlinear Acoustic Response of Phospholipid-Coated Microbubbles with pH for Ultrasound Imaging.ACS sensors · 2024Article
- Microbubble Contrast Agents Improve Detection of Active Hemorrhage.IEEE open journal of engineering in medicine and biology · 2024Article
- Generalized mathematical framework for contrast-enhanced ultrasound imaging with pulse inversion spectral deconvolution.Ultrasonics · 2023Article
- Faster super-resolution ultrasound imaging with a deep learning model for tissue decluttering and contrast agent localization.Biomedical physics & engineering express · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The use of super-resolution ultrasound (SR-US) imaging greatly improves visualization of microvascular structures, but clinical adoption is limited by long imaging times. This method depends on detecting and localizing isolated microbubbles (MBs), forcing the use of a dilute contrast agent concentration. Contrast-enhanced ultrasound (CEUS) image acquisition times as long as minutes arise as the localization of thousands of MBs are acquired to form a complete SR-US image. In this article, we explore the use of nonlinear CEUS strategies using nonlinear fundamental contrast pulse sequencing (CPS) to increase the contrast-to-tissue ratio (CTR) and compare MB detection effectiveness to linear B-mode CEUS imaging. The CPS compositions of amplitude modulation (AM), pulse inversion (PI), and a combination of the two (AMPI) were studied. A simulation study combined the Rayleigh-Plesset-Marmottant (RPM) model of MB characteristics and a nonlinear tissue model using the k-Wave toolbox for MATLAB (MathWorks Inc., Natick, MA, USA). Validation was conducted using an in vitro flow phantom and in vivo in the rat hind-limb. Imaging was performed with a programmable US scanner (Vantage 256, Verasonics Inc., Kirkland, WA, USA) and customized to transmit a set of basis US pulses from which both B-mode US (frame rate (FR) of 800 Hz) and multiple nonlinear CPS compositions (FR of 200 Hz) could be assessed from identical in vitro and in vivo datasets using a near simultaneous method. The simulations suggest that MB characteristics, such as diameter and motion, help to predict which US imaging strategy will enhance MB detection. The in vitro and in vivo US imaging studies revealed that different subpopulations of polydisperse MB contrast agents were detected by linear imaging and by each different nonlinear CPS composition. The most effective single imaging strategy at a 200-Hz FR was found to be B-mode US imaging. However, a combination of B-mode US imaging with a nonlinear CPS imaging strategy was more effective in detecting MBs in vivo at all depths and was shown to shorten image acquisition time by an average of 33.3%-76.7% when combining one or more CPS sequences.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.