ArticleDiabetes care2021
Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes.
Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed.
- Association of socioeconomic status and lifestyle factors with incident diabetes among individuals with prediabetes: a prospective cohort study from UK Biobank.Preventive medicine reports · 2026Article
- Predicting incident type 2 diabetes using wearable activity and polygenic risk: A survival-modeling study in All of Us.The Journal of clinical endocrinology and metabolism · 2026Article
- Associations Between Screen Exposure, Multidimensional Sleep Indicators, and Type 2 Diabetes: A Cross-sectional Study Using US National Survey Data.Journal of diabetes science and technology · 2026Article
- GLP-1 receptor agonist therapy and skeletal muscle: A narrative review synthesizing adult evidence with implications for older adults.JAR life · 2026Review
- Association between device-measured physical activities, type 2 diabetes, and life expectancy over the next 10 years: a prospective longitudinal study.BMC public health · 2025Article
- Replacement of leisure-time sedentary behavior with various physical activities and the risk of osteopenia and osteoporosis: evidence from the UK Biobank.Journal of exercise science and fitness · 2025Article
- Prospective associations between muscle strength and genetic susceptibility to type 2 diabetes with incident type 2 diabetes: a UK Biobank study.BMC medicine · 2025Article
- Aerobic exercise improves inflammation and insulin resistance in skeletal muscle by regulating miR-221-3p via JAK/STAT signaling pathway.Frontiers in physiology · 2025Article
- Replacement of sedentary behavior with various physical activities and the risk of all-cause and cause-specific mortality.BMC medicine · 2024Article
- Effects of replacing sedentary time with alterations in physical activity or sleep on mood states in Chinese young adults during the pandemic.BMC public health · 2024Article
- Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study.Journal of sport and health science · 2024Article
- Different types of screen time, physical activity, and incident dementia, Parkinson's disease, depression and multimorbidity status.The international journal of behavioral nutrition and physical activity · 2023Article
- Replacing of sedentary behavior with physical activity and the risk of mortality in people with prediabetes and diabetes: a prospective cohort study.The international journal of behavioral nutrition and physical activity · 2023Article
- Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis.Journal of the Endocrine Society · 2023Article
- Life's Essential 8, Genetic Susceptibility, and Incident Cardiovascular Disease: A Prospective Study.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- The importance of exercise for glycemic control in type 2 diabetes.American journal of medicine open · 2023Article
- Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality: A prospective cohort study.Journal of sport and health science · 2023Article
- Validation of Genome-Wide Association Studies (GWAS)-Identified Type 2 Diabetes Mellitus Risk Variants in Pakistani Pashtun Population.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Physical activity, sedentary behavior, and cardiovascular disease risk in Korea: a trajectory analysis.Epidemiology and health · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo prospectively analyze the association of sedentary behavior time with type 2 diabetes (T2D) risk and perform the isotemporal substitution analyses to estimate the effect of substitution of sedentary behaviors by equal time of different types of daily-life physical activities and structured exercise. We also examined modifications by the genetic predisposition to T2D. RESEARCH DESIGN AND
methodsWe included 475,502 participants free of T2D in the UK Biobank. Sedentary time was quantified by summing up the time spent on television watching, computer use, and driving.
resultsDuring a median follow-up of 11 years, we documented 18,169 incident T2D cases. In comparison of the extreme categories (≥6 vs. <2 h/day), the hazard ratio for T2D was 1.58 (95% CI 1.47, 1.71) after adjustment for age, race, sex, lifestyle factors, and other covariates. Replacing 30 min of sedentary behavior per day with an equal amount of time of different types of daily-life activities and structured exercise was significantly associated with a 6-31% risk reduction of T2D, with strenuous sports showing the strongest (31%, 95% CI 24, 37) benefit. Moreover, we found a significant interaction between sedentary behavior and genetic predisposition for the risk of T2D (
conclusionsOur study indicates that sedentary behavior time is associated with an increased risk of T2D; replacing sedentary behavior with a short duration (30 min/day) of daily-life physical activities or structured exercise is related to a significant reduction in T2D risk. Furthermore, such association was stronger among those with a lower genetic risk of T2D.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.