ArticleMolecular medicine reports2021
Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p.Biology direct · 2024Article
- The Carcinogenic Potential of Bisphenol A in the Liver Based on Transcriptomic Studies.Cancers · 2023Article
- CircTNPO3 promotes hepatocellular carcinoma progression by sponging miR-199b-5p and regulating STRN expression.The Kaohsiung journal of medical sciences · 2023Article
- The SMAD2/miR-4256/HDAC5/p16Oncology research · 2023Article
- miR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer‑related death worldwide. The aim of the present study was to discuss the role of circular RNA (circRNA) dedicator of cytokinesis 1 (DOCK1) in HCC and whether it can affect cell proliferation, invasion and migration by regulating the microRNA (miR)‑654‑5p/SMAD2 axis. The expression levels of circRNA DOCK1, miR‑654‑5p and SMAD2 mRNA in HCC cells and transfected Hep3b cells were detected by reverse transcription‑quantitative PCR analysis. SMAD2 protein expression levels in HCC cells and transfected Hep3b cells were analyzed by western blot analysis. The viability, proliferation, migration and invasion of transfected Hep3b cells was in turn detected by Cell Counting Kit‑8, clone formation, wound healing and Transwell assays. The interaction of circRNA DOCK1 and miR‑654‑5p, miR‑654‑5p and SMAD2 was confirmed by the dual‑luciferase reporter assay. As a result, the expression of circRNA DOCK1 and SMAD2 was increased, and miR‑654‑5p was decreased in HCC cells. circRNA DOCK1 directly targeted to miR‑654‑5p and miR‑654‑5p directly targeted to SMAD2. Interference with circRNA DOCK1 inhibited the proliferation, invasion and migration of HCC cells by upregulating miR‑654‑5p expression. The effects of circRNA DOCK1 knockdown could be partially reversed by transfection with a miR‑654‑5p inhibitor and SMAD2 overexpression. In conclusion, interference with circRNA DOCK1 inhibited proliferation, invasion and migration of HCC cells by regulating the miR‑654‑5p/SMAD2 axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.