Evidence map›Paper›PMID 34184431›Full record

ArticlePhysiological reports2021

Impact of sodium glucose linked cotransporter-2 inhibition on renal microvascular oxygen tension in a rodent model of diabetes mellitus.

Gregory M T Hare, Yanling Zhang, Kyle Chin, Kerri Thai, Evelyn Jacobs, Melina P Cazorla-Bak, Linda Nghiem, David F Wilson, Sergei A Vinogradov, Kim A Connelly and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
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  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. SGLT-2 Inhibitors in Heart Failure: A Review of Current Evidence.International journal of heart failure · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors.International journal of molecular sciences · 2022
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gregory M T HareDepartment of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-4641-4818
Yanling ZhangKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Kyle ChinDepartment of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Kerri ThaiKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Evelyn JacobsDepartment of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Melina P Cazorla-BakDepartment of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Linda NghiemKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
David F WilsonDepartment of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kim A ConnellyDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
C David MazerDepartment of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Roger G EvansCardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Vic, Australia.
Richard E GilbertKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Funding

Oxygen imaging by phosphorescence quenchingU24EB028941 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2019 to 2023
$1.6M
NIBIB NIH HHS U24 EB028941
6 · The paper itself

Abstract

backgroundThe mechanisms whereby inhibitors of sodium-glucose linked cotransporter-2 (SGLT2) exert their nephroprotective effects in patients with diabetes are incompletely understood but have been hypothesized to include improved tissue oxygen tension within the renal cortex. The impact of SGLT2 inhibition is likely complex and region specific within the kidney. We hypothesize that SGLT2 inhibitors have differential effects on renal tissue oxygen delivery and consumption in specific regions of the diabetic kidney, including the superficial cortex, containing SGLT2-rich components of proximal tubules, versus the deeper cortex and outer medulla, containing predominantly SGLT1 receptors.

methodsWe measured glomerular filtration rate (GFR), microvascular kidney oxygen tension (P

resultsIn diabetic rats treated with dapagliflozin, measurement within the superficial cortex (blue light) demonstrated no change in P

conclusionsThese findings indicate that microvascular kidney oxygen tension is maintained in the superficial cortex but reduced in deeper cortical and outer medullary tissue, possibly due to the regional impact of SGLT-2 inhibition on tissue metabolism. This reduction in deeper P

Indexed as

AnimalsBenzhydryl CompoundsDiabetes Mellitus, ExperimentalErythropoietinGlomerular Filtration RateGlucosidesKidneyMaleMicrovesselsOxygenRatsRats, Sprague-DawleySodium-Glucose Transporter 2 InhibitorsBenzhydryl CompoundsdapagliflozinErythropoietinGlucosidesOxygenSodium-Glucose Transporter 2 Inhibitors

Identifiers

PMID34184431
PMCPMC8239445

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.