Evidence map›Paper›PMID 34188694›Full record

ReviewInterventional cardiology (London, England)2021

What an Interventionalist Needs to Know About MI with Non-obstructive Coronary Arteries.

Robert Sykes, Daniel Doherty, Kenneth Mangion, Andrew Morrow, Colin Berry

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Interventional cardiology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05198791 (The Effect of Mineralocorticoid Receptor Antagonist Therapy in Patients With Acute Myocardial Infection or Injury and no Obstructive Coronary Arteries), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05198791 phase2recruitingnot on this mapstarted 2022, after this paper: background citation

The Effect of Mineralocorticoid Receptor Antagonist Therapy in Patients With Acute Myocardial Infection or Injury and no Obstructive Coronary Arteries: a Registry-based, Stratified-medicine, Randomized, Controlled Trial

TypeinterventionalSponsorNHS National Waiting Times Centre BoardRan2022 to 2026Enrolled400ConditionsMyocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries, Myocardial InjuryArmsStratified medicine - Microvascular dysfunction and eplerenone therapy, tablets, Stratification and standard care
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. MINOCA as the result of coronary artery aneurysm thrombosis.The Journal of international medical research · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. MINOCA: Myocardial infarction no obstructive coronary artery disease.American heart journal plus : cardiology research and practice · 2023
    Review
  11. Review
  12. Sex Differences in Acute Coronary Syndromes: A Global Perspective.Journal of cardiovascular development and disease · 2022
    Review
  13. Role of CT and MRI in Cardiac Emergencies.Tomography (Ann Arbor, Mich.) · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robert SykesWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow, UK.
Daniel DohertyWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow, UK.
Kenneth MangionWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow, UK.
Andrew MorrowWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow, UK.
Colin BerryWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital Glasgow, UK.
Golden Jubilee National Hospital · GBNHS Greater Glasgow and Clyde · GB

Funding

British Heart Foundation PG/17/25/32884Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

MI with non-obstructive coronary arteries (MINOCA) is caused by a heterogeneous group of vascular or myocardial disorders. MINOCA occurs in 5.15% of patients presenting with acute ST-segment elevation MI or non-ST segment elevation MI and prognosis is impaired. The diagnosis of MINOCA is made during coronary angiography following acute MI, where there is no stenosis ≥50% present in an infarct-related epicardial artery and no overt systemic aetiology for the presentation. Accurate diagnosis and subsequent management require the appropriate utilisation of intravascular imaging, coronary function testing and subsequent imaging to assess for myocardial disorders without coronary involvement. Although plaque-related MINOCA is currently managed with empirical secondary prevention strategies, there remains an unmet therapeutic need for targeted and evidence-based therapy for MINOCA patients and increased awareness of the recommended diagnostic pathway.

Indexed as

acute coronary syndromeinterventional cardiologyMIMINOCAnon-obstructive coronary artery disease

Identifiers

PMID34188694
PMCPMC8218171
OpenAlexW3169212407

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.