Evidence map›Paper›PMID 34189448›Full record

ReviewJHEP reports : innovation in hepatology2021

Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma.

Zobair M Younossi, Linda Henry

Open access · goldAbstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.

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  18. TREM2-expressing macrophages in liver diseases.Trends in endocrinology and metabolism: TEM · 2026
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Zobair M YounossiCenter for Liver Disease and Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, United States.
Linda HenryCenter for Outcomes Research in Liver Diseases, Washington DC, United States.
Center for Outcomes Research in Liver Diseases · USInova Fairfax Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide, whereas that of most other cancers is decreasing. Non-alcoholic fatty liver disease (NAFLD), which has increased with the epidemics of obesity and type 2 diabetes, increases the risk of HCC. Interestingly, NAFLD-associated HCC can develop in patients with or without cirrhosis. A lack of awareness about NAFLD-related HCC has led to delays in diagnosis. Therefore, a large number of patients with HCC are diagnosed with advanced-stage HCC with low 5-year survival. In this context, increasing awareness of NAFLD and NAFLD-related HCC may lead to earlier diagnosis and more effective interventions.

Indexed as

ALD, alcohol-related liver diseaseawarenesscirrhosisCVD, cardiovascular diseaseELF, enhanced liver fibrosisFIB-4, fibrosis-4HCC, hepatocellular carcinomaNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisnatural historynon-cirrhosisPDGF, platelet-derived growth factorSTAT3, signal transducer and activator of transcription 3surveillanceTNF, tumour necrosis factor-αVEGF, vascular endothelial growth factor

Identifiers

PMID34189448
PMCPMC8215299
OpenAlexW3163483026

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.