ArticleThe Journal of nutrition2021
Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study.
Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Workplace food purchases, dietary intake, and gut microbial metabolites in a secondary analysis of the ChooseWell 365 study.The American journal of clinical nutrition · 2024Trial
- Salmon Food-Specific Compounds and Their Metabolites Increase in Human Plasma and Are Associated with Cardiometabolic Health Indicators Following a Mediterranean-Style Diet Intervention.The Journal of nutrition · 2024Trial
- A narrative review of dietary patterns in cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2026Review
- Metabolomic profiles of an atherogenic TMAO-dietary pattern among postmenopausal women.European journal of nutrition · 2025Article
- Article
- Serum and urine metabolite correlates of vitamin D supplementation in the Atherosclerosis Risk in Communities (ARIC) study.Clinical nutrition ESPEN · 2025Article
- High-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Metabolic Mechanisms Underlying the Association Between the Profertility Diet and In Vitro Fertilization End Points.The Journal of nutrition · 2025Article
- Serum metabolite signature of the modified Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Association between plant-based diet quality and chronic kidney disease in Australian adults.Public health nutrition · 2024Article
- Serum Metabolomic Markers of Protein-Rich Foods and Incident CKD: Results From the Atherosclerosis Risk in Communities Study.Kidney medicine · 2024Article
- Plasma lipidomic markers of diet quality are associated with incident coronary heart disease in American Indian adults: the Strong Heart Family Study.The American journal of clinical nutrition · 2024Article
- Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2024Article
- Metabolomic Biomarkers of Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns in Pregnant Women.Nutrients · 2024Article
- Role of metabolomics in the delivery of precision nutrition.Redox biology · 2023Article
- Nutritional Epidemiology and Dietary Assessment for Patients With Kidney Disease: A Primer.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Review
- Metabolomic biomarkers of the mediterranean diet in pregnant individuals: A prospective study.Clinical nutrition (Edinburgh, Scotland) · 2023Article
- Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study.JCI insight · 2022Article
- Serum metabolomic signatures of plant-based diets and incident chronic kidney disease.The American journal of clinical nutrition · 2022Article
- Clinical Effect of Mudan Granule on Peripheral Neuritis Caused by Chronic Renal Insufficiency.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundIn individuals with chronic kidney disease (CKD), healthy dietary patterns are inversely associated with CKD progression. Metabolomics, an approach that measures many small molecules in biofluids, can identify biomarkers of healthy dietary patterns.
objectivesWe aimed to identify known metabolites associated with greater adherence to 4 healthy dietary patterns in CKD patients.
methodsWe examined associations between 486 known plasma metabolites and Healthy Eating Index (HEI)-2015, Alternative Healthy Eating Index (AHEI)-2010, the Dietary Approaches to Stop Hypertension (DASH) diet, and alternate Mediterranean diet (aMED) in 1056 participants (aged 21-74 y at baseline) in the Chronic Renal Insufficiency Cohort (CRIC) Study. Usual dietary intake was assessed using a semiquantitative FFQ. We conducted multivariable linear regression models to study associations between healthy dietary patterns and individual plasma metabolites, adjusting for sociodemographic characteristics, health behaviors, and clinical factors. We used principal component analysis to identify groups of metabolites associated with individual food components within healthy dietary patterns.
resultsAfter Bonferroni correction, we identified 266 statistically significant diet-metabolite associations (HEI: n = 60; AHEI: n = 78; DASH: n = 77; aMED: n = 51); 78 metabolites were associated with >1 dietary pattern. Lipids with a longer acyl chain length and double bonds (unsaturated) were positively associated with all 4 dietary patterns. A metabolite pattern low in saturated diacylglycerols and triacylglycerols, and a pattern high in unsaturated triacylglycerols was positively associated with intake of healthy food components. Plasmalogens were negatively associated with the consumption of nuts and legumes and healthy fat, and positively associated with the intake of red and processed meat.
conclusionsWe identified many metabolites associated with healthy dietary patterns, indicative of food consumption. If replicated, these metabolites may be considered biomarkers of healthy dietary patterns in patients with CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.