Evidence map›Paper›PMID 34196824›Full record

ReviewCurrent cardiology reports2021

PET Imaging of Post-infarct Myocardial Inflammation.

Andrej Ćorović, Meritxell Nus, Ziad Mallat, James H F Rudd, Jason M Tarkin

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. An innovative hybrid imaging protocol for whole-bodyCardio-oncology (London, England) · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrej ĆorovićDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
Meritxell NusDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
Ziad MallatDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
James H F RuddDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
Jason M TarkinDivision of Cardiovascular Medicine, University of Cambridge, Cambridge, UK. jt545@cam.ac.uk.ORCID http://orcid.org/0000-0002-9132-120X

Funding

British Heart Foundation CH/10/001/27642British Heart Foundation FS/20/23/34784British Heart Foundation FS/CRTF/20/24035Department of HealthMedical Research Council MR/N028015/1Wellcome TrustWellcome Trust 211100/Z/18/Z
6 · The paper itself

Abstract

purpose of reviewTo examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT

findingsDysregulated immune responses after myocardial infarction are associated with adverse cardiac remodelling and an increased likelihood of ischaemic heart failure. PET imaging utilising novel tracers can be applied to visualise different components of the post-infarction inflammatory and repair processes. This approach could offer unique pathophysiological insights that could prove useful for the identification and risk-stratification of individuals who would ultimately benefit most from emerging immune-modulating therapies. PET imaging could also bridge the clinical translational gap as a surrogate measure of drug efficacy in early-stage clinical trials in patients with myocardial infarction. The use of hybrid PET/MR imaging, in particular, offers the additional advantage of simultaneous in vivo molecular imaging and detailed assessment of myocardial function, viability and tissue characterisation. Further research is needed to realise the true clinical translational value of PET imaging after myocardial infarction.

Indexed as

Fluorodeoxyglucose F18Myocardial InfarctionHumansInflammationMyocardiumPositron-Emission TomographyFluorodeoxyglucose F18Heart failureInflammationMolecular imagingMyocardial infarctionNon-invasive imagingPET

Identifiers

PMID34196824
PMCPMC8249287

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.