Evidence map›Paper›PMID 34198955›Full record

ArticleMolecules (Basel, Switzerland)2021

Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes.

Patrizia N Hanieh, Jacopo Forte, Chiara Di Meo, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantù, Federica Rinaldi, Carlotta Marianecci, Maria Carafa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Bioadhesive hybrid system of niosomes and pH sensitiveSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Patrizia N HaniehDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.ORCID 0000-0003-3278-8376
Jacopo ForteDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.
Chiara Di MeoDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.ORCID 0000-0002-3531-6107
Maria Grazia AmmendoliaCentro Nazionale Tecnologie Innovative in Sanità Pubblica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00162 Rome, Italy.ORCID 0000-0003-4121-3005
Elena Del FaveroLaboratorio Interdisciplinare Tecnologie Avanzate (L.I.T.A.), Department of Medical Biotechnologies and Translational Medicine, University of Milan, Via Fratelli Cervi 93, 20090 Segrate, Italy.ORCID 0000-0002-6584-1869
Laura CantùLaboratorio Interdisciplinare Tecnologie Avanzate (L.I.T.A.), Department of Medical Biotechnologies and Translational Medicine, University of Milan, Via Fratelli Cervi 93, 20090 Segrate, Italy.
Federica RinaldiDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.
Carlotta MarianecciDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.ORCID 0000-0002-2505-1766
Maria CarafaDipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzle A. Moro 5, 00185 Roma, Italy.ORCID 0000-0002-3968-3385
Sapienza University of Rome · ITUniversity of Milan · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chemically modified to tailor its physico-chemical properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span

Indexed as

AnimalsBiomimetic MaterialsCattleCell MembraneCholesterolDrug Delivery SystemsDrug StabilityHyaluronan ReceptorsHyaluronic AcidLiposomesNanostructuresParticle SizeSerumCholesterolHyaluronan ReceptorsHyaluronic AcidLiposomesfluorescenceHA-Chol derivativemimetic membranesniosomesSAXSTEMtumor targeting

Identifiers

PMID34198955
PMCPMC8201220
OpenAlexW3172893987

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.