Evidence map›Paper›PMID 34199726›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Simulated Gastric Digestion and In Vivo Intestinal Uptake of Orally Administered CuO Nanoparticles and TiO

Ninell P Mortensen, Maria Moreno Caffaro, Shyam Aravamudhan, Lakshmi Beeravalli, Sharmista Prattipati, Rodney W Snyder, Scott L Watson, Purvi R Patel, Frank X Weber, Stephanie A Montgomery and 2 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
  10. Oral administration of TiOParticle and fibre toxicology · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ninell P MortensenRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-7980-8958
Maria Moreno CaffaroRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.
Shyam AravamudhanJoint School of Nanoscience and Nanoengineering, 2907 East Gate City Blvd., Greensboro, NC 27401, USA.
Lakshmi BeeravalliJoint School of Nanoscience and Nanoengineering, 2907 East Gate City Blvd., Greensboro, NC 27401, USA.
Sharmista PrattipatiJoint School of Nanoscience and Nanoengineering, 2907 East Gate City Blvd., Greensboro, NC 27401, USA.
Rodney W SnyderRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.
Scott L WatsonRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-9442-0502
Purvi R PatelRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.
Frank X WeberRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8012-5302
Susan J SumnerUNC Nutrition Research Institute, The University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC 28081, USA.
Timothy R FennellRTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Early life ENM-exposure and the impact on neurobehavioral and cardiovascular outcomes and biochemical mechanismsU01ES027254 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND, SUMNER, SUSAN J · 2016 to 2020
$2.6M
NCI NIH HHS P30 CA016086NIEHS NIH HHS U01 ES027254NIEHS NIH HHS U01ES027254
6 · The paper itself

Abstract

Oral exposure to nanoparticles (NPs) during early life is an understudied area. The goals of this study were to evaluate the effect of pre-weaned rat gastric fluids on 50 nm CuO NPs and TiO

Indexed as

CuO nanoparticlesearly life exposureENM stabilityfood grade TiO2 E171immune cellsoral administrationrat pupssimulated gastric digestiontissue uptake

Identifiers

PMID34199726
PMCPMC8230348

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.