Evidence map›Paper›PMID 34199819›Full record

ArticleJournal of personalized medicine2021

Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder.

Rita Barone, Jean Bastin, Fatima Djouadi, Indrapal Singh, Mohammad Azharul Karim, Amrit Ammanamanchi, Patrick John McCarty, Leanna Delhey, Rose Shannon, Antonino Casabona and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Rita BaroneDepartment of Clinical and Experimental Medicine, Child Neuropsychiatry Section, University of Catania, 95124 Catania, Italy.ORCID 0000-0001-6302-2686
Jean BastinCentre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 75006 Paris, France.
Fatima DjouadiCentre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 75006 Paris, France.ORCID 0000-0003-0350-0935
Indrapal SinghBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
Mohammad Azharul KarimBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
Amrit AmmanamanchiBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
Patrick John McCartyBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
Leanna DelheyArkansas Children's Research Institute, Little Rock, AR 72758, USA.ORCID 0000-0003-1301-6952
Rose ShannonArkansas Children's Research Institute, Little Rock, AR 72758, USA.
Antonino CasabonaDepartment of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, 95124 Catania, Italy.ORCID 0000-0003-0180-4695
Renata RizzoDepartment of Clinical and Experimental Medicine, Child Neuropsychiatry Section, University of Catania, 95124 Catania, Italy.
Richard Eugene FryeBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ 85016, USA.ORCID 0000-0003-4442-2937
Barrow Neurological Institute · USUniversity of Catania · ITArkansas Children's Hospital · USInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with autism spectrum disorder (ASD) may have an increase in blood acyl-carnitine (AC) concentrations indicating a mitochondrial fatty acid β-oxidation (mtFAO) impairment. However, there are no data on systematic mtFAO analyses in ASD. We analyzed tritiated palmitate oxidation rates in fibroblasts from patients with ASD before and after resveratrol (RSV) treatment, according to methods used for the diagnosis of congenital defects in mtFAO. ASD participants (

Indexed as

acyl-carnitinesautism spectrum disorderenergy metabolismfatty acid oxidationresveratrol

Identifiers

PMID34199819
PMCPMC8229571
OpenAlexW3171389798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.