Evidence map›Paper›PMID 34200247›Full record

ArticleCells2021

Natural Compounds and PCL Nanofibers: A Novel Tool to Counteract Stem Cell Senescence.

Emanuela Bellu, Sara Cruciani, Giuseppe Garroni, Francesca Balzano, Rosanna Satta, Maria Antonia Montesu, Angela Fadda, Maurizio Mulas, Giorgia Sarais, Pasquale Bandiera and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  5. Effect ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Emanuela BelluDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.ORCID 0000-0001-8632-2577
Giuseppe GarroniDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.ORCID 0000-0002-0389-2142
Francesca BalzanoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.ORCID 0000-0002-9966-2930
Rosanna SattaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Maria Antonia MontesuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Angela FaddaIstituto di Scienze delle Produzioni Alimentari (ISPA), Consiglio Nazionale delle Ricerche (CNR), Traversa la Crucca 3, 07100 Sassari, Italy.ORCID 0000-0002-1384-5956
Maurizio MulasDepartment of Agriculture, University of Sassari, Via De Nicola 9, 07100 Sassari, Italy.ORCID 0000-0002-4773-8104
Giorgia SaraisDepartment of Life and Environmental Sciences, University of Cagliari, University Campus, 09042 Monserrato (Cagliari), Italy.ORCID 0000-0002-6297-2687
Pasquale BandieraDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.ORCID 0000-0002-0589-4539
Carlo VenturaLaboratory of Molecular Biology and Stem Cell Engineering-Eldor Lab, National Institute of Biostructures and Biosystems, Innovation Accelerator, CNR, Via Piero Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0001-9333-0321
Martin KralovičInstitute of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic.
Jan SaboDepartment of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 04011 Košice, Slovakia.
Evzen AmlerInstitute of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.ORCID 0000-0003-0187-4968
University of Sassari · ITCharles University · CZInstitute of Sciences of Food Production · ITUniversity of Cagliari · ITUniversity of Pavol Jozef Šafárik · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue homeostasis mainly depends on the activity of stem cells to replace damaged elements and restore tissue functions. Within this context, mesenchymal stem cells and fibroblasts are essential for maintaining tissue homeostasis in skin, in particular in the dermis. Modifications in collagen fibers are able to affect stem cell features. Skin properties can be significantly reduced after injuries or with aging, and stem cell niches, mainly comprising extracellular matrix (ECM), may be compromised. To this end, specific molecules can be administrated to prevent the aging process induced by UV exposure in the attempt to maintain a youngness phenotype. NanoPCL-M is a novel nanodevice able to control delivery of Mediterranean plant myrtle (

Indexed as

PhytochemicalsPlant ExtractsAdipose TissueCellular SenescenceFibroblastsHumansMyrtusNanofibersStem CellsPhytochemicalsPlant Extractscell senescencecellular mechanismsnanofibersnatural extractsskin agingstem cells

Identifiers

PMID34200247
PMCPMC8227046
OpenAlexW3166064683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.