ReviewNutrients2021
Aspartame-True or False? Narrative Review of Safety Analysis of General Use in Products.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Aspartame and Neurotoxicity: Quantitative Insights from Biomarker and Dose-response Analysis.Current neurovascular research · 2026Pooled it
- Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems.Medicina (Kaunas, Lithuania) · 2026Review
- Effects of artificial sweeteners on coronary heart disease: A 2-way 2-sample Mendelian randomization study and mediation analysis.Medicine · 2026Article
- Prescription of vitamin D in neonates and infants under one year of age in Spain: an eight-year observational study.BMC primary care · 2026Observational
- Investigating the relationship between taste perception of artificial sweeteners and cancer risk.Public health nutrition · 2026Article
- No indication of histological changes in embryonic somatosensory cortex development upon maternal aspartame consumption in mice.NPJ science of food · 2026Article
- The Safety Profile of Aspartame: A Review of Regulatory Standards and Emerging Health Concerns.Journal of nutrition and metabolism · 2026Review
- Aspartame may promote erectile dysfunction via DPP4-mediated endothelial dysfunction and apoptosis: evidence from network toxicology, molecular dynamics simulation, and experimental validation.Frontiers in nutrition · 2026Article
- Olive oil-derived monounsaturated fat influences metabolic signatures in serotonergic regions of the brain in broiler chicken.Frontiers in physiology · 2026Article
- Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review.Foods (Basel, Switzerland) · 2025Review
- Analysis of toxicity and mechanisms of aspartame in kidney stones with network toxicology and molecular docking strategy.Scientific reports · 2025Article
- Article
- Sesame oil ameliorates aspartame-induced immunotoxicity in mice: a hematological, antioxidative, and histopathological evaluation.Journal of molecular histology · 2025Article
- Beyond Sugar: A Holistic Review of Sweeteners and Their Role in Modern Nutrition.Foods (Basel, Switzerland) · 2025Review
- Potential Effects of Low-Calorie Sweeteners on Human Health.Nutrients · 2025Review
- Aspartame and Human Health: A Mini-Review of Carcinogenic and Systemic Effects.Journal of xenobiotics · 2025Review
- Metagenomics and transcriptomics analysis of aspartame's impact on gut microbiota and glioblastoma progression in a mouse model.Scientific reports · 2025Article
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Rediscovering Sweetness: The Evolution and Impact of Non-Nutritive and Natural Sweeteners.Current nutrition reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. Schlatter in 1965. Being 180-200 times sweeter than sucrose, its intake was expected to reduce obesity rates in developing countries and help those struggling with diabetes. It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains controversial. This narrative review investigates the existing literature on the use of aspartame and its possible effects on the human body to refine current knowledge. Taking to account that aspartame is a widely used artificial sweetener, it seems appropriate to continue research on safety. Studies mentioned in this article have produced very interesting results overall, the current review highlights the social problem of providing visible and detailed information about the presence of aspartame in products. The studies involving the impact of aspartame on obesity, diabetes mellitus, children and fetus, autism, neurodegeneration, phenylketonuria, allergies and skin problems, its cancer properties and its genotoxicity were analyzed. Further research should be conducted to ensure clear information about the impact of aspartame on health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.