Evidence map›Paper›PMID 34200582›Full record

ArticleInternational journal of molecular sciences2021

Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.

Alejandro Ogazon Del Toro, Lidia Jimenez, Mauricio Serrano Rubi, Marcelino Cereijido, Arturo Ponce

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024
    Review
  3. Endogenous Cardiac Steroids in Bipolar Disorder: State of the Art.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alejandro Ogazon Del ToroDepartment of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Lidia JimenezDepartment of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Mauricio Serrano RubiDepartment of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Marcelino CereijidoDepartment of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Arturo PonceDepartment of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City 07360, Mexico.
Center for Research and Advanced Studies of the National Polytechnic Institute · MX

Funding

CONACYT Mexico 285263
6 · The paper itself

Abstract

Ouabain is a cardiac glycoside that has been described as a hormone, with interesting effects on epithelial physiology. We have shown previously that ouabain induces gap junctional intercellular communication (GJIC) in wild, sensitive cells (MDCK-S), but not in cells that have become insensitive (MDCK-I) by modifying their Na

Indexed as

Paracrine CommunicationAnimalsCardiotonic AgentsDinoprostoneDogsGap JunctionsMadin Darby Canine Kidney CellsOuabainSignal TransductionCardiotonic AgentsDinoprostoneOuabaindye transfergap junctionsouabainprostaglandin E2

Identifiers

PMID34200582
PMCPMC8230150
OpenAlexW3168578222

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.