Evidence map›Paper›PMID 34200937›Full record

ReviewInternational journal of molecular sciences2021

Uremic Toxins and Frailty in Patients with Chronic Kidney Disease: A Molecular Insight.

Chia-Ter Chao, Shih-Hua Lin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Frailty Among Patients With ADPKD.Kidney international reports · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chia-Ter ChaoNephrology Division, Department of Internal Medicine, National Taiwan University Hospital BeiHu Branch, Taipei 10845, Taiwan.ORCID 0000-0003-2892-7986
Shih-Hua LinNephrology Division, Department of Internal Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
National Defense Medical Center · TWNational Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 109-2314-B-002-193-MY3Ter-Zer Foundation for Educational Achievement
6 · The paper itself

Abstract

The accumulation of uremic toxins (UTs) is a prototypical manifestation of uremic milieu that follows renal function decline (chronic kidney disease, CKD). Frailty as a potential outcome-relevant indicator is also prevalent in CKD. The intertwined relationship between uremic toxins, including small/large solutes (phosphate, asymmetric dimethylarginine) and protein-bound ones like indoxyl sulfate (IS) and

Indexed as

AnimalsFrailtyHumansQuality of LifeRenal Insufficiency, ChronicToxins, BiologicalUremiaToxins, Biologicaladvanced glycation endproductchronic inflammationchronic kidney diseasecytokinesfrail phenotypefrailtyindoxyl sulfateoxidative stressp-cresyl sulfatesenescenceuremic toxins

Identifiers

PMID34200937
PMCPMC8230495
OpenAlexW3166384713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.