Evidence map›Paper›PMID 34201349›Full record

ReviewDiagnostics (Basel, Switzerland)2021

Role of Contrast-Enhanced Ultrasound (CEUS) in Native Kidney Pathology: Limits and Fields of Action.

Antonio Granata, Irene Campo, Paolo Lentini, Francesco Pesce, Loreto Gesualdo, Antonio Basile, Vito Cantisani, Matthias Zeiler, Michele Bertolotto

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Isoechoic Renal Tumors: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Contrast-enhanced ultrasound in renal cystic lesions: an update.Journal of medical ultrasonics (2001) · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Antonio GranataNephrology and Dialysis Unit, "Cannizzaro" Hospital, 95026 Catania, Italy.ORCID 0000-0002-7026-3952
Irene CampoDepartment of Radiology, "Civile di Conegliano" Hospital, ULSS 2 Marca Trevigiana, 31015 Conegliano, Italy.ORCID 0000-0001-8008-6606
Paolo LentiniNephrology and Dialysis Unit, San Bassiano Hospital, 36061 Bassano del Grappa, Italy.
Francesco PesceNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Antonio BasileRadiology Unit I, Department of Medical Surgical Sciences and Advanced Technologies "GF Ingrassia"-University Hospital "Policlinico-San Marco", University of Catania, 95123 Catania, Italy.
Vito CantisaniDepartment of Radiology, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.
Matthias ZeilerNephrology and Dialysis Unit, "Carlo Urbani" Hospital, 60035 Jesi, Italy.
Michele BertolottoDepartment of Radiology, "Cattinara" Hospital, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0001-5583-350X
University of Bari Aldo Moro · ITOspedale Cannizzaro · ITOspedale San Bassiano · ITPoliclinico Umberto I · ITUniversity of Catania · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gray scale ultrasound has an important diagnostic role in native kidney disease. Low cost, absence of ionizing radiation and nephrotoxicity, short performance time, and repeatability even at the bedside, are the major advantages of this technique. The introduction of contrast enhancement ultrasound (CEUS) in daily clinical practice has significantly reduced the use of contrast enhancement computed tomography (CECT) and contrast enhancement magnetic resonance (CEMR), especially in patients with renal disease. Although there are many situations in which CECT and CEMRI are primarily indicated, their use may be limited by the administration of the contrast medium, which may involve a risk of renal function impairment, especially in the elderly, and in patients with acute kidney injury (AKI) and moderate to severe chronic kidney disease (CKD). In these cases, CEUS can be a valid diagnostic choice. To date, numerous publications have highlighted the role of CEUS in the study of parenchymal micro-vascularization and renal pathology by full integration with second level imaging methods (CECT and CEMRI) both in patients with normal renal function and with diseased kidneys. The aim of this review is to offer an updated overview of the limitations and potential applications of CEUS in native kidney disease.

Indexed as

CEUSchronic kidney diseasecontrast-enhanced ultrasoundmicrobubblesnephropathiesrenal diseaseultrasonography

Identifiers

PMID34201349
PMCPMC8226824
OpenAlexW3172889409

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.