Evidence map›Paper›PMID 34201504›Full record

ArticleCancers2021

Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma.

Julia Paczkowska, Joanna Janiszewska, Adam Ustaszewski, Julia Bein, Marcin Skalski, Agnieszka Dzikiewicz-Krawczyk, Natalia Rozwadowska, Martin-Leo Hansmann, Sylvia Hartmann, Maciej Giefing

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Julia PaczkowskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-3976-4353
Joanna JaniszewskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-1765-0152
Adam UstaszewskiInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-9542-0029
Julia BeinDr. Senckenberg Institute of Pathology, Goethe University Frankfurt, D-60590 Frankfurt, Germany.
Marcin SkalskiInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Agnieszka Dzikiewicz-KrawczykInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0001-7633-2114
Natalia RozwadowskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-5111-0870
Martin-Leo HansmannDr. Senckenberg Institute of Pathology, Goethe University Frankfurt, D-60590 Frankfurt, Germany.
Sylvia HartmannDr. Senckenberg Institute of Pathology, Goethe University Frankfurt, D-60590 Frankfurt, Germany.ORCID 0000-0003-3424-1091
Maciej GiefingInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-4760-8246
Institute of Human Genetics · PLGoethe University Frankfurt · DE

Funding

European Union's Horizon 2020 research and innovation programme No 952304German Research Foundation DFG, HA6145/3-1Polish National Science Center 2014/14/M/NZ2/00529Polish National Science Center 2019/32/T/NZ5/00441
6 · The paper itself

Abstract

A hallmark of classical Hodgkin lymphoma (cHL) is the attenuation of B-cell transcription factors leading to global transcriptional reprogramming. The role of miRNAs (microRNAs) involved in this process is poorly studied. Therefore, we performed global miRNA expression profiling using RNA-seq on commonly used cHL cell lines, non-Hodgkin lymphoma cell lines and sorted normal CD77

Indexed as

B-cell transcription factorsclassical Hodgkin lymphomaloss of B-cell phenotypemicrodissectionmiRNANF-κB

Identifiers

PMID34201504
PMCPMC8269295
OpenAlexW3173456918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.