Evidence map›Paper›PMID 34202215›Full record

ArticleInternational journal of molecular sciences2021

Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model.

Bokyung Song, Sung-Joong Lee, Chong-Hyun Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. The 5-HT and PLC Signaling Pathways Regulate the Secretion of IL-1Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bokyung SongCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID 0000-0002-3803-0235
Sung-Joong LeeProgram in Neuroscience, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Korea.
Chong-Hyun KimCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID 0000-0002-0968-4176
Korea Institute of Brain Science · KRSeoul National University · KR

Funding

Korea Institute of Science and Technology 2E30190Korea Institute of Science and Technology 2E30762National Research Foundation of Korea 2016M3C7A1905119
6 · The paper itself

Abstract

Cytokines are important neuroinflammatory modulators in neurodegenerative brain disorders including traumatic brain injury (TBI) and stroke. However, their temporal effects on the physiological properties of microglia and neurons during the recovery period have been unclear. Here, using an ATP-induced cortical injury model, we characterized selective effects of ATP injection compared to needle-control. In the damaged region, the fluorescent intensity of CX

Indexed as

Membrane PotentialsAdenosine TriphosphateAnimalsBrain Injuries, TraumaticCerebral CortexCytokinesDisease Models, AnimalDisease SusceptibilityGene ExpressionGenes, ReporterMiceMicrogliaNeuronsPurinergic AntagonistsAdenosine TriphosphateCytokinesPurinergic AntagonistsATP injurycortexcytokineexcitabilitymicrogliapotassium channelpurinergic receptor

Identifiers

PMID34202215
PMCPMC8268462
OpenAlexW3174843266

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.