Evidence map›Paper›PMID 34209167›Full record

ReviewJournal of personalized medicine2021

Exploring the Oral Microbiome in Rheumatic Diseases, State of Art and Future Prospective in Personalized Medicine with an AI Approach.

Silvia Bellando-Randone, Edda Russo, Vincenzo Venerito, Marco Matucci-Cerinic, Florenzo Iannone, Sabina Tangaro, Amedeo Amedei

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Article
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  12. Article
  13. Article
  14. Periodontal bacteria influence systemic diseases through the gut microbiota.Frontiers in cellular and infection microbiology · 2024
    Review
  15. Review
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  17. Gut dysbiosis in autoimmune diseases: Association with mortality.Frontiers in cellular and infection microbiology · 2023
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Silvia Bellando-RandoneDepartment of Clinical and Experimental Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Edda RussoDepartment of Clinical and Experimental Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0003-3141-1091
Vincenzo VeneritoRheumatology Unit, Department of Emergency and Organ Transplantations, University of Bari "Aldo Moro", 70121 Bari, Italy.
Marco Matucci-CerinicDepartment of Clinical and Experimental Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
Florenzo IannoneRheumatology Unit, Department of Emergency and Organ Transplantations, University of Bari "Aldo Moro", 70121 Bari, Italy.
Sabina TangaroDipartimento Interateneo di Fisica "M. Merlin", Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70121 Bari, Italy.ORCID 0000-0002-1372-3916
Amedeo AmedeiDepartment of Clinical and Experimental Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.ORCID 0000-0002-6797-9343
University of Florence · ITUniversity of Bari Aldo Moro · ITIstituto Nazionale di Fisica Nucleare, Sezione di Bari · ITVita-Salute San Raffaele University · IT

Funding

Ente Cassa di Risparmio di Firenze 2019
6 · The paper itself

Abstract

The oral microbiome is receiving growing interest from the scientific community, as the mouth is the gateway for numerous potential etiopathogenetic factors in different diseases. In addition, the progression of niches from the mouth to the gut, defined as "oral-gut microbiome axis", affects several pathologies, as rheumatic diseases. Notably, rheumatic disorders (RDs) are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. In this review, we examine evidence which supports a role for the oral microbiome in the etiology and progression of various RDs, including rheumatoid arthritis (RA), Sjogren's syndrome (SS), and systemic lupus erythematosus (SLE). In addition, we address the most recent studies endorsing the oral microbiome as promising diagnostic biomarkers for RDs. Lastly, we introduce the concepts of artificial intelligence (AI), in particular, machine learning (ML) and their general application for understanding the link between oral microbiota and rheumatic diseases, speculating the application of a possible AI approach-based that can be applied to personalized medicine in the future.

Indexed as

artificial intelligencebiomarkersmachine learningmicrobiomeoral microbiotarheumatoid arthritisrheumatology diseasesSjogren’s syndromesystemic lupus erythematosus

Identifiers

PMID34209167
PMCPMC8306274
OpenAlexW3174851702

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.