Evidence map›Paper›PMID 34209576›Full record

ArticleInternational journal of molecular sciences2021

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination.

Suvarin Pavasutthipaisit, Melanie Stoff, Tim Ebbecke, Malgorzata Ciurkiewicz, Sabine Mayer-Lambertz, Theresa Störk, Kevin D Pavelko, Bernd Lepenies, Andreas Beineke

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Suvarin PavasutthipaisitDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0003-4395-5766
Melanie StoffDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-8034-000X
Tim EbbeckeCenter for Systems Neuroscience, 30559 Hannover, Germany.
Malgorzata CiurkiewiczDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-6277-7366
Sabine Mayer-LambertzInstitute for Immunology and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Theresa StörkDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Kevin D PavelkoDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7555-1315
Bernd LepeniesCenter for Systems Neuroscience, 30559 Hannover, Germany.
Andreas BeinekeDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
University of Veterinary Medicine Hannover, Foundation · DEMayo Clinic · US

Funding

Deutsche Forschungsgemeinschaft BE 4200/1 3 & LE 2498/6-1
6 · The paper itself

Abstract

Neurotropic viruses target the brain and contribute to neurologic diseases. Caspase recruitment domain containing family member 9 (CARD9) controls protective immunity in a variety of infectious disorders. To investigate the effect of CARD9 in neurotropic virus infection, CARD9

Indexed as

Disease SusceptibilityAnimalsBiomarkersCARD Signaling Adaptor ProteinsDisease Models, AnimalEncephalitis, ViralGenetic Predisposition to DiseaseHippocampusHost-Pathogen InteractionsImmunohistochemistryLymphocyte SubsetsMiceMice, KnockoutPicornaviridaePicornaviridae InfectionsViral LoadBiomarkersCard9 protein, mouseCARD Signaling Adaptor ProteinsCARD9hippocampal damageneurotropic virusTheiler’s murine encephalomyelitis virus

Identifiers

PMID34209576
PMCPMC8268812
OpenAlexW3174139777

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.