Evidence map›Paper›PMID 34209681›Full record

ReviewMolecules (Basel, Switzerland)2021

Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds.

Samson Olaitan Oselusi, Alan Christoffels, Samuel Ayodele Egieyeh

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Local anesthetics as a tool for Staphylococcus spp. control: a systematic review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Exploring the Antibacterial Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Effect ofFrontiers in cellular and infection microbiology · 2024
    Article
  9. BioMed research international · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Samson Olaitan OselusiSchool of Pharmacy, University of the Western Cape, Bellville, Cape Town 7535, South Africa.ORCID 0000-0003-4736-0823
Alan ChristoffelsSouth African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Cape Town 7535, South Africa.ORCID 0000-0002-0420-2916
Samuel Ayodele EgieyehSchool of Pharmacy, University of the Western Cape, Bellville, Cape Town 7535, South Africa.ORCID 0000-0002-7462-6669
University of the Western Cape · ZASouth African Medical Research Council · ZA

Funding

South African Research Chairs Initiative of the Department of Science and Innovation and National Re-search Foundation of South Africa UID 64751The APC charges were funded by the SA Medical Research Council nil
6 · The paper itself

Abstract

The growing antimicrobial resistance (AMR) of pathogenic organisms to currently prescribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the increasing drug resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have been shown to display promising in vitro activities against multidrug-resistant pathogens. Still, only a few of these compounds have been studied as prospective drug candidates. This may be due to the expensive and time-consuming process of conducting important studies on these compounds. The present review focuses on applying cheminformatics strategies to characterize, prioritize, and optimize NPs to develop new lead compounds against antimicrobial resistance pathogens. Moreover, case studies where these strategies have been used to identify potential drug candidates, including a few selected open-access tools commonly used for these studies, are briefly outlined.

Indexed as

Anti-Infective AgentsBiological ProductsDrug ResistanceHumansLeadAnti-Infective AgentsBiological ProductsLeadantimicrobial resistancecheminformaticsdrug-likenesshit-optimizationhit prioritizationnatural products

Identifiers

PMID34209681
PMCPMC8271829
OpenAlexW3176215051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.