Evidence map›Paper›PMID 34209900›Full record

ArticleInternational journal of molecular sciences2021

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling.

Ji-Hye Jang, Min-Seong Kim, Ainsley Mike Antao, Won-Jun Jo, Hyung-Joon Kim, Su-Jin Kim, Myeong-Jun Choi, Suresh Ramakrishna, Kye-Seong Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ji-Hye JangGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Min-Seong KimGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Ainsley Mike AntaoGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Won-Jun JoGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.
Hyung-Joon KimGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.ORCID 0000-0001-6700-2033
Su-Jin KimAxceso Biopharma Co., Ltd., Yongin 16914, Korea.
Myeong-Jun ChoiAxceso Biopharma Co., Ltd., Yongin 16914, Korea.
Suresh RamakrishnaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.ORCID 0000-0002-4038-1085
Kye-Seong KimGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, Korea.ORCID 0000-0001-5550-1660
Hanyang University · KR

Funding

National Research Foundation of Korea 2017M3A9B3061830
6 · The paper itself

Abstract

Adult human cardiomyocytes have an extremely limited proliferative capacity, which poses a great barrier to regenerative medicine and research. Human embryonic stem cells (hESCs) have been proposed as an alternative source to generate large numbers of clinical grade cardiomyocytes (CMs) that can have potential therapeutic applications to treat cardiac diseases. Previous studies have shown that bioactive lipids are involved in diverse cellular responses including cardiogenesis. In this study, we explored the novel function of the chemically synthesized bioactive lipid O-cyclic phytosphingosine-1-phosphate (cP1P) as an inducer of cardiac differentiation. Here, we identified cP1P as a novel factor that significantly enhances the differentiation potential of hESCs into cardiomyocytes. Treatment with cP1P augments the beating colony number and contracting area of CMs. Furthermore, we elucidated the molecular mechanism of cP1P regulating SMAD1/5/8 signaling via the ALK3/BMP receptor cascade during cardiac differentiation. Our result provides a new insight for cP1P usage to improve the quality of CM differentiation for regenerative therapies.

Indexed as

Bone Morphogenetic Protein Receptors, Type ICell DifferentiationCells, CulturedGene Expression RegulationHuman Embryonic Stem CellsHumansLipidsMyocytes, CardiacSignal TransductionSphingosineBMPR1A protein, humanBone Morphogenetic Protein Receptors, Type ILipidsphytosphingosine-1-phosphateSphingosinebioactive lipidsbiomoleculescardiac differentiationcardiac injurycardiogenic transcription factorscardiomyocyte differentiation

Identifiers

PMID34209900
PMCPMC8267745
OpenAlexW3175118597

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.