ArticleNature human behaviour2021
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Article in Nature human behaviour, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.BMC psychiatry · 2024Pooled it
- Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.Nature genetics · 2023Pooled it
- Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank.Sexual medicine · 2026Article
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model.Archives of women's mental health · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Psychosis as a multisystem disorder of aberrant aging.npj aging · 2026Review
- Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.Nature genetics · 2026Article
- Genetic Association of Sexual Behavior, Sildenafil, and Hormonal Contraceptives With Mental Disorders.CNS neuroscience & therapeutics · 2026Article
- Exploring the genetic overlap between substance use disorder and educational attainment.Addiction (Abingdon, England) · 2026Article
- Unraveling the link between early sexual initiation and endometriosis: evidence from population-based analyses and genetic causal inference.Reproductive biology and endocrinology : RB&E · 2026Article
- Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals.Molecular psychiatry · 2026Article
- Maternal smoking during pregnancy, other reproductive factors, and neonatal jaundice: A two-sample Mendelian randomization study.Tobacco induced diseases · 2026Article
- The role of social and genetic factors in partnership trajectories and later life health.Scientific reports · 2025Article
- Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses.Cell reports. Medicine · 2025Observational
- Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization.Neurology. Genetics · 2025Article
- Shared biological pathways linking ADHD and cortisol variability are related to externalizing behaviors.Psychoneuroendocrinology · 2025Article
- Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes.BMC medicine · 2025Article
- Article
- Bidirectional causality between female reproductive traits and temporomandibular disorders.Journal of oral & facial pain and headache · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.