Evidence map›Paper›PMID 34213593›Full record

ReviewIntensive care medicine2021

Acute kidney injury in the critically ill: an updated review on pathophysiology and management.

Peter Pickkers, Michael Darmon, Eric Hoste, Michael Joannidis, Matthieu Legrand, Marlies Ostermann, John R Prowle, Antoine Schneider, Miet Schetz

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 314 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
314citing papers in PubMed, 7 pooled it
42.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

314 citing papers in PubMed, 7 syntheses or guidelines pooled it, 480 citations in OpenAlex.

  1. Pooled it
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  8. Trial
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  11. Predictive Value of Anion Gap for Acute Kidney Injury Progression and Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Trial
  12. Review
  13. Article
  14. Article
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  16. Article
  17. Review
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  19. Article
  20. Rewiring the mitochondrial NADMaterials today. Bio · 2026
    Article

254 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 7 countries.

Peter PickkersDepartment of Intensive Care, Radboud University Medical Centre, PO Box 9101, NL 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-1104-4303
Michael DarmonAPHP, Service de médecine intensive et de réanimation, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.ORCID http://orcid.org/0000-0003-4198-8038
Eric HosteDepartment of Intensive Care Medicine, Ghent University Hospital, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0001-9301-8055
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Matthieu LegrandDepartment of Anesthesia and Peri-Operative Care, Division of Critical Care Medicine, University of California San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0001-9788-5316
Marlies OstermannDepartment of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, SE1 9RT, UK.ORCID http://orcid.org/0000-0001-9500-9080
John R ProwleAdult Critical Care Unit, Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-5002-2721
Antoine SchneiderAdult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0576-7094
Miet SchetzClinical Department and Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven University, Herestraat 49, B3000, Leuven, Belgium. marie.schetz@uzleuven.be.ORCID http://orcid.org/0000-0001-5776-4827
Ghent University Hospital · BEInnsbruck Medical University · ATInserm · FRKU Leuven · BEQueen Mary University of London · GBRadboud University Nijmegen · NLSt Thomas' Hospital · GBUniversity Hospital of Lausanne · CHUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient's long-term prognosis. In this narrative review, an update on various aspects of AKI in critically ill patients will be provided. Focus will be on prediction and early detection of AKI (e.g., the role of biomarkers to identify high-risk patients and the use of machine learning to predict AKI), aspects of pathophysiology and progress in the recognition of different phenotypes of AKI, as well as an update on nephrotoxicity and organ cross-talk. In addition, prevention of AKI (focusing on fluid management, kidney perfusion pressure, and the choice of vasopressor) and supportive treatment of AKI is discussed. Finally, post-AKI risk of long-term sequelae including incident or progression of chronic kidney disease, cardiovascular events and mortality, will be addressed.

Indexed as

Acute Kidney InjuryCritical IllnessBiomarkersHumansKidneyPrognosisBiomarkersAcute kidney injuryBiomarkersBlood pressure managementDiagnosisFluid therapyHeterogeneityLong-term consequencesMachine learningNephrotoxicityOrgan cross-talkPathophysiologyPhenotypesVasopressor

Identifiers

PMID34213593
PMCPMC8249842
OpenAlexW3177086065

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.