Evidence map›Paper›PMID 34213838›Full record

ReviewJournal of cellular and molecular medicine2021

Engineering Tools for Regulating Hypoxia in Tumour Models.

Min Hee Kim, Steven D Green, Chien-Chi Lin, Heiko Konig

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Research progress of metabolomics in cervical cancer.European journal of medical research · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Gas-modulating microcapsules for spatiotemporal control of hypoxia.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Article
  8. Engineering Tools for Regulating Hypoxia in Tumour Models.Journal of cellular and molecular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Min Hee KimDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, US.
Steven D GreenDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, US.
Chien-Chi LinDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, US.ORCID 0000-0002-4175-8796
Heiko KonigDepartment of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, US.ORCID 0000-0002-6871-7388
Indiana University Health · USUniversity of Indianapolis · USUniversity School · US

Funding

BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia: Admin SuppR01CA227737 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, CHIEN-CHI · 2019 to 2022
$1.5M
NCI NIH HHS R01 CA227737NCI NIH HHS R01CA227737
6 · The paper itself

Abstract

Major advances in the field of genomic technologies have led to an improvement in cancer diagnosis, classification and prognostication. However, many cancers remain incurable due to the development of drug resistance, minimal residual disease (MRD) and disease relapse, highlighting an incomplete understanding of the mechanisms underlying these processes. In recent years, the impact of non-genetic factors on neoplastic transformations has increasingly been acknowledged, and growing evidence suggests that low oxygen (O

Indexed as

Tumor MicroenvironmentBioengineeringHumansHypoxiaNeoplasm, ResidualNeoplasmsNeoplastic Stem Cells

Identifiers

PMID34213838
PMCPMC8358887
OpenAlexW3174806522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.