Evidence map›Paper›PMID 34215331›Full record

ArticleStem cell research & therapy2021

Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.

Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  13. Kidney fibrosis: from mechanisms to therapeutic medicines.Signal transduction and targeted therapy · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Extracellular vesicles in kidney disease.Nature reviews. Nephrology · 2022
    Review
  18. Article
  19. Molecular Mechanisms of Kidney Injury and Repair.International journal of molecular sciences · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lu YuSchool of Medicine, Nankai University, Tianjin, 300071, China.
Siying LiuSchool of Medicine, Nankai University, Tianjin, 300071, China.
Chen WangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Chuanyu ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Yajie WenSchool of Medicine, Nankai University, Tianjin, 300071, China.
Kaiyue ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Shang ChenSchool of Medicine, Nankai University, Tianjin, 300071, China.
Haoyan HuangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Yue LiuSchool of Medicine, Nankai University, Tianjin, 300071, China.
Lingling WuState Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China.
Zhongchao HanBeijing Engineering Laboratory of Perinatal Stem Cells, Beijing Institute of Health and Stem Cells, Health & Biotech Co., Beijing, China.
Xiangmei ChenState Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China. xmchen301@126.com.
Zongjin LiSchool of Medicine, Nankai University, Tianjin, 300071, China. zongjinli@nankai.edu.cn.
Na LiuSchool of Medicine, Nankai University, Tianjin, 300071, China. liuna@nankai.edu.cn.ORCID 0000-0003-3832-5591
Nankai University · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmbryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acute and severe disease in clinical practice, which seriously threatens human life and health. However, the roles and mechanisms of ESC-EVs on AKI remain unclear.

methodsIn this study, we evaluated the effects of ESC-EVs on physiological repair and pathological repair using murine ischemia-reperfusion injury-induced AKI model, the potential mechanisms of which were next investigated. EVs were isolated from ESCs and EVs derived from mouse fibroblasts as therapeutic controls. We then investigated whether ESC-EVs can restore the structure and function of the damaged kidney by promoting physiological repair and inhibiting the pathological repair process after AKI in vivo and in vitro.

resultsWe found that ESC-EVs significantly promoted the recovery of the structure and function of the damaged kidney. ESC-EVs increased the proliferation of renal tubular epithelial cells, facilitated renal angiogenesis, inhibited the progression of renal fibrosis, and rescued DNA damage caused by ischemia and reperfusion after AKI. Finally, we found that ESC-EVs play a therapeutic effect by activating Sox9

conclusionsESC-EVs significantly promote the physiological repair and inhibit the pathological repair after AKI, enabling restoration of the structure and function of the damaged kidney. This strategy might emerge as a novel therapeutic strategy for ESC clinical application.

Indexed as

Acute Kidney InjuryExtracellular VesiclesMesenchymal Stem CellsAnimalsEmbryonic Stem CellsKidneyMiceAcute kidney injury (AKI)Embryonic stem cell (ESC)Extracellular vesicles (EVs)Pathological repairPhysiological repair

Identifiers

PMID34215331
PMCPMC8254253
OpenAlexW3174131045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.