Evidence map›Paper›PMID 34215725›Full record

ArticleCell death & disease2021

Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration.

Irina V Saltykova, Asif Elahi, Priyam M Pitale, Oleg S Gorbatyuk, Mohammad Athar, Marina S Gorbatyuk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Mechanism of Cone Degeneration in Retinitis Pigmentosa.Cellular and molecular neurobiology · 2023
    Review
  10. Article
  11. Methods for In Vivo Characterization of Proteostasis in the Mouse Retina.Advances in experimental medicine and biology · 2023
    Article
  12. GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice.International journal of molecular sciences · 2022
    Article
  13. Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. A Novel Tree Shrew Model of Diabetic Retinopathy.Frontiers in endocrinology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Irina V SaltykovaDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Asif ElahiDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Priyam M PitaleDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0033-7039
Oleg S GorbatyukDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Mohammad AtharDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Marina S GorbatyukDepartment of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA. mgortk@uab.edu.ORCID 0000-0001-9060-856X
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
Post-translational histone modification in ocular tissues of mice exposed to arsenicalsR01EY027763 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GORBATYUK, MARINA · 2018 to 2022
$2.0M
Development and Validation of a Tree Shrew Model of Diabetic RetinopathyR21EY031103 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GORBATYUK, MARINA · 2019 to 2019
$297k
NEI NIH HHS R01 EY027763NEI NIH HHS R21 EY031103NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/mTOR signaling in rd16 retinas, in which we restored the AKT/mTOR axis by genetic ablation of pseudokinase TRB3, known to inhibit phosphorylation of AKT and mTOR. First, we found that TRB3 ablation resulted in preservation of photoreceptor function in degenerating retinas. Then, we learned that the mTOR downstream cellular pathways involved in the homeostasis of photoreceptors were also reprogrammed in rd16 TRB3

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAutophagosomesAutophagyAutophagy-Related Protein 5Beclin-1Cell Cycle ProteinsDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutPhosphorylationPhotoreceptor Cells, VertebrateProto-Oncogene Proteins c-aktRetinal DegenerationRhodopsinAdaptor Proteins, Signal TransducingAtg5 protein, mouseAutophagy-Related Protein 5Beclin-1Becn1 protein, mouseCell Cycle ProteinsEif4ebp1 protein, mousemTOR protein, mouseparkin proteinProto-Oncogene Proteins c-aktRhodopsinTOR Serine-Threonine KinasesTRB3 protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID34215725
PMCPMC8253859
OpenAlexW3177208387

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.