Evidence map›Paper›PMID 34219716›Full record

ArticleJournal of Alzheimer's disease : JAD2021

Neuroticism Is Associated with Tau Pathology in Cognitively Unimpaired Individuals with Autosomal Dominant Alzheimer's Disease.

Ana Baena, Yamile Bocanegra, Valeria Torres, Clara Vila-Castelar, Edmarie Guzmán-Vélez, Joshua T Fox-Fuller, Jennifer R Gatchel, Justin Sánchez, Celina F Pluim, Liliana Ramirez-Gómez and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana BaenaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.
Yamile BocanegraGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.
Valeria TorresDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Clara Vila-CastelarDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Edmarie Guzmán-VélezDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Joshua T Fox-FullerDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jennifer R GatchelDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Justin SánchezDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Celina F PluimDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Liliana Ramirez-GómezDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jairo MartínezDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
David PinedaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.
Francisco LoperaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.
Yakeel T QuirozGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8M
Memory network dysfunction as an early marker of preclinical Alzheimer's DiseaseDP5OD019833 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2014 to 2018
$2.3M
Aerobic fitness as a modifier of neurodegeneration and cognitive decline in preclinical Alzheimer's diseaseK23AG061276 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GUZMÁN-VÉLEZ, EDMARIE · 2019 to 2023
$881k
Working Memory in Preclinical Alzheimer's Disease: a Neuropsychological and Neuroimaging InvestigationF31AG062158 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI FULLER, JOSHUA THOMAS · 2019 to 2021
$117k
NIA NIH HHS F31 AG062158NIA NIH HHS K23 AG061276NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG054671NIH HHS DP5 OD019833
6 · The paper itself

Abstract

backgroundGreater neuroticism has been associated with higher risk for Alzheimer's disease (AD) dementia. However, the directionality of this association is unclear. We examined whether personality traits differ between cognitively-unimpaired carriers of autosomal-dominant AD (ADAD) and non-carriers, and are associated with in vivo AD pathology.

objectiveTo determine whether personality traits differ between cognitively unimpaired ADAD mutation carriers and non-carriers, and whether the traits are related to age and AD biomarkers.

methodsA total of 33 cognitively-unimpaired Presenilin-1 E280A mutation carriers and 41 non-carriers (ages 27-46) completed neuropsychological testing and the NEO Five-Factor Personality Inventory. A subsample (n = 46; 20 carriers) also underwent tau and amyloid PET imaging.

resultsCarriers reported higher neuroticism relative to non-carriers, although this difference was not significant after controlling for sex. Neuroticism was positively correlated with entorhinal tau levels only in carriers, but not with amyloid levels.

conclusionThe finding of higher neuroticism in carriers and the association of this trait with tau pathology in preclinical stages of AD highlights the importance of including personality measures in the evaluation of individuals at increased risk for cognitive impairment and dementia. Further research is needed to characterize the mechanisms of these relationships.

Indexed as

Alzheimer DiseaseNeuroticismProdromal SymptomsAdultAmyloid beta-PeptidesBiomarkersFemaleHumansMaleMutationNeuropsychological TestsPersonality TestsPositron-Emission TomographyPresenilin-1tau ProteinsAmyloid beta-PeptidesBiomarkersPresenilin-1tau ProteinsAlzheimer’s diseasebiomarkersneuroticismpersonalitypreclinicalpresenilin-1

Identifiers

PMID34219716
PMCPMC9113533

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.