Evidence map›Paper›PMID 34222845›Full record

ArticleiScience2021

p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of

Jewon Jung, Han Liao, Shannon A Coker, Hong Liang, John F Hancock, Catherine Denicourt, Kartik Venkatachalam

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jewon JungDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
Han LiaoDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
Shannon A CokerDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
Hong LiangDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
John F HancockDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
Catherine DenicourtDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
Kartik VenkatachalamDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.
The University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · US

Funding

Effects of senescence to Alzheimer's disease pathologyR01AG068076 · NIA · MAYO CLINIC ROCHESTER · PI BAKER, DARREN · 2020 to 2024
$2.0M
Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesRF1AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2020 to 2020
$1.8M
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathyRF1AG072176 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2021 to 2021
$1.2M
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathyR01AG072176 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARTIK VENKATACHALAM · 2025 to 2026
$766k
Modulation of mitochondrial proliferation and function in Drosophila neuronsR21AG061646 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SARDIELLO, MARCO, VENKATACHALAM, KARTIK · 2018 to 2019
$443k
Involvement of an ER to lysosome signaling axis in the onset of neurodegeneration in models of ADR21AG067414 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2020 to 2020
$421k
NIA NIH HHS R01 AG068076NIA NIH HHS R01 AG072176NIA NIH HHS R21 AG061646NIA NIH HHS R21 AG067414NIA NIH HHS RF1 AG069076NIA NIH HHS RF1 AG072176
6 · The paper itself

Abstract

Inhibition of TRPML1, which is encoded by

Indexed as

Biological SciencesCancerCell BiologyMolecular Biology

Identifiers

PMID34222845
PMCPMC8243020
OpenAlexW3170518469

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.