Evidence map›Paper›PMID 34224700›Full record

ArticleEuropean journal of pharmacology2021

Molecular signaling of synthetic cannabinoids: Comparison of CB1 receptor and TRPV1 channel activation.

Haley K Andersen, Kenneth B Walsh

Open access · greenAbstract readComparative Study
In one paragraph

Article in European journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Terpenes inInternational journal of molecular sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Haley K AndersenDepartment of Pharmacology, Physiology, & Neuroscience, University of South Carolina, School of Medicine, Columbia, SC, USA.
Kenneth B WalshDepartment of Pharmacology, Physiology, & Neuroscience, University of South Carolina, School of Medicine, Columbia, SC, USA. Electronic address: walsh@uscmed.sc.edu.
University of South Carolina · US

Funding

Real Time Screening for GIRK1/4 Channel BlockersR21NS071530 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WALSH, KENNETH B · 2010 to 2010
$137k
NINDS NIH HHS R21 NS071530
6 · The paper itself

Abstract

Recreational use of synthetic cannabinoids (SCs) is associated with desirable euphoric and relaxation effects as well as adverse effects including anxiety, agitation and psychosis. These SC-mediated actions represent a combination of potentiated cannabinoid receptor signaling and "off-target" receptor activity. The goal of this study was to compare the efficacy of various classes of SCs in stimulating CB

Indexed as

CannabinoidsReceptor, Cannabinoid, CB1Signal TransductionTRPV Cation ChannelsAnimalsCalciumG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHEK293 CellsHumansCalciumCannabinoidsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsReceptor, Cannabinoid, CB1TRPV Cation ChannelsFluorescence measurementsG protein-gated inward rectifier K(+) channelSynthetic cannabinoidsTransient potential receptor channels

Identifiers

PMID34224700
PMCPMC8374946
OpenAlexW3175204971

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.